The Medical Applications of Nanomaterials in the Central Nervous System

Carbon Nanotubes: Smart Drug/Gene Delivery Carriers

“…In recent decades, research in the field of biotechnology has focused on nanotechnology and nanomaterials. 1,2 Nanomaterials are especially well suited for medical applications because of their unique properties including facile synthesis, controllable size, tunable surface chemistry, large surface-to-volume ratios and significant biocompatibility; all considered as promising for almost all aspects of biotechnology to overcome the many limitations in existing conventional materials. 3 For instance, pioneering research conducted by Higuchi et al on albumin nanoparticles indicated that nanomedicine may be an effective treatment for cancer due to their ability to avoid immune system clearance enhancing tumor and cancer cell targeting.…”

Neurotoxicity of Nanomaterials: An Up-to-Date Overview

“…To date, because nanomaterials can act as Trojan horses, they have been used as carriers for the delivery of drugs and imaging probes to specific cells and tissues [19]. Tremendous efforts have been made in developing nanomedicines for the diagnosis and therapy for the effective treatment of various brain diseases, including brain cancer, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and ischemic stroke [20,21,22].…”

Progress in cancer drug delivery based on AS1411 oriented nanomaterials

“…After in vivo injection, fluorescently labeled AS1411 is targeted to photoreceptors and retinal pigment epithelium and other retinal cell types [ 138 ]. AS1411 is a nucleoprotein targeting aptamer that has been tested as an anticancer agent in Phase II clinical trials [ 139 ].Various nanomaterials have been used to deliver different kinds of drugs and probes in the treatment of diseases of the axial nervous system [ 140 ]. In order to achieve a better application prospect in 786-0 molecular magnetic resonance imaging of renal cancer, the AS1411-polyethylene glycol-manganese dioxide nanoprobe formed by covalent coupling reaction was prepared in 2018 [ 141 ] using the stability of polyethylene glycol-manganese dioxide nanoparticles.…”