The Medicinal Uses of Cannabis and Cannabinoids

Guy, Geoffrey W.; Whittle, B. A.; Robson, Philip

doi:10.1016/s0768-9179(08)70455-3

Cited by 31 publications

(45 citation statements)

References 24 publications

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“…In ancient Greece, Rome, China and India, it was used to ameliorate muscle spasms, cramps and pain [1]. At the end of the 19th century in Europe, cannabis was most commonly used for the treatment of pain, asthma, sleep disorders, depression, and loss of appetite [2]. Its medicinal use continued until the fi rst half of the 20th century, when cannabis became subject to legal restrictions due to its psychoactive potential.…”

Section: Introductionmentioning

confidence: 99%

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Stojanović¹,

Tomas²,

Paut-Kusturica³

et al. 2017

Hosp Pharm Int Multi J

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SUMMARYIntroduction: With the growing trend for legalization of cannabis and its derivatives in Serbia, pharmacists are likely to be consulted on the safety, effi cacy, and drug-drug or drug-disease interactions of medical cannabis. Thus, the aim of our study was to assess pharmacy students' knowledge and attitude toward medical cannabis use in Serbia to determine if additional education is needed. Subjects and methods: In the study students from the fi nal year of the study program of integrated academic studies of pharmacy at the Faculty of Medicine, University of Novi Sad were asked to complete an anonymous questionnaire regarding their knowledge and attitudes on the use of cannabis and its derivatives in medical purposes. After giving their written informed consent, they were instructed by the researchers on how to complete the questionnaire. All questionnaires were administered between August 1, 2017 and August 15, 2017. The study was approved by the Ethical Committee of the Faculty of Medicine in Novi Sad; a total of 80 questionnaires were distributed. The questionnaire consisted of 3 groups of statements on which they should mark level of their agreement related to students' knowledge about the use of cannabis and its derivatives in therapeutical purposes, potential negative eff ects, dispensing in a pharmacy and legalization of cannabis and its derivatives in medical purposes. Results: Although 91.2% of the respondents agreed that cannabis and its derivatives could potentially have therapeutical eff ects, much lower percentage of respondents (51.3%) were familiar with possible therapeutical eff ects of cannabis. The same percentage of respondents learned about therapeutical eff ects of cannabis from sources other than school. About third (31.3%) of our respondents thought that the use of cannabis and its derivatives in therapeutical purposes could cause their abuse and the similar percentage of respondents (33.8%) thought that issuing cannabis and its derivatives in the pharmacy could expose a pharmacist to the certain dangers such as insisting on the issuing without the prescription or robbery. About 90% of the respondents agreed it is necessary to create clear guidelines for the use of cannabis and its derivatives in therapeutical purposes and 76.3% of the respondents thought that doctor's prescription is necessary for their dispensing in a pharmacy. Most of the respondents (75%) agreed that, based on the experiences of the countries which have

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Section: Introductionmentioning

confidence: 99%

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Stojanović¹,

Tomas²,

Paut-Kusturica³

et al. 2017

Hosp Pharm Int Multi J

View full text Add to dashboard Cite

show abstract

“…Male gender, older age at the time of HCV infection, duration of HCV infection, heavy alcohol consumption and coinfection with human immunodeficiency virus (HIV) have been identified as risk factors for fibrosis progression (2)(3)(4)(5) Cannabis (Cannabis sativa) has a long history of use for medicinal and recreational purposes and is commonly used throughout the world (6). Cannabis is the source of over 60 cannabinoid compounds, including δ 9 -tetrahydrocannabinol (δ 9 -THC), which is primarily responsible for the psychoactive effects of the plant (7). Cannabinoid compounds bind to G protein-coupled receptors called CB1, which predominate in the central nervous system, and CB2, which are expressed mainly by immune cells (7).…”

Section: Introductionmentioning

confidence: 99%

“…Cannabis is the source of over 60 cannabinoid compounds, including δ 9 -tetrahydrocannabinol (δ 9 -THC), which is primarily responsible for the psychoactive effects of the plant (7). Cannabinoid compounds bind to G protein-coupled receptors called CB1, which predominate in the central nervous system, and CB2, which are expressed mainly by immune cells (7). Cannabinoid receptor expression is upregulated in cirrhotic livers compared to normal livers.…”

Section: Introductionmentioning

confidence: 99%

Influence of Cannabis Use on Severity of Hepatitis C Disease

Ishida

Peters

Jin

et al. 2008

Clinical Gastroenterology and Hepatology

128

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“…The Cannabis plant has a long and colourful history that spans more than 5000 years of world history and human usage [1][2][3][4] . In contemporary times, the term "cannabis" has commonly been supplanted by the more colloquial term "marijuana" (also spelled "marihuana").…”

Section: Introductionmentioning

confidence: 99%

“…In contemporary times, the term "cannabis" has commonly been supplanted by the more colloquial term "marijuana" (also spelled "marihuana"). An extremely versatile and easily cultivatable plant, Cannabis was used by ancient cultures for food, fibre, and medicinal purposes [1][2][3][4] . In the 20th century, it was a topic of much folklore, pop culture, controversy, and loathing.…”

Section: Introductionmentioning

confidence: 99%

A User’s Guide to Cannabinoid Therapies in Oncology

Maida

Daeninck

2016

Current Oncology

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ABSTRACT"Cannabinoid" is the collective term for a group of chemical compounds that either are derived from the Cannabis plant, are synthetic analogues, or occur endogenously. Although cannabinoids interact mostly at the level of the currently recognized cannabinoid receptors, they might have cross reactivity, such as at opioid receptors.Patients with malignant disease represent a cohort within health care that have some of the greatest unmet needs despite the availability of a plethora of guideline-driven disease-modulating treatments and pain and symptom management options. Cannabinoid therapies are varied and versatile, and can be offered as pharmaceuticals (nabilone, dronabinol, and nabiximols), dried botanical material, and edible organic oils infused with cannabis extracts. Cannabinoid therapy regimens can be creative, involving combinations of all of the aforementioned modalities. Patients with malignant disease, at all points of their disease trajectory, could be candidates for cannabinoid therapies whether as monotherapies or as adjuvants.The most studied and established roles for cannabinoid therapies include pain, chemotherapy-induced nausea and vomiting, and anorexia. Moreover, given their breadth of activity, cannabinoids could be used to concurrently optimize the management of multiple symptoms, thereby reducing overall polypharmacy. The use of cannabinoid therapies could be effective in improving quality of life and possibly modifying malignancy by virtue of direct effects and in improving compliance or adherence with disease-modulating treatments such as chemotherapy and radiation therapy.

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The Medicinal Uses of Cannabis and Cannabinoids

Cited by 31 publications

References 24 publications

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Influence of Cannabis Use on Severity of Hepatitis C Disease

A User’s Guide to Cannabinoid Therapies in Oncology

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