The medicinal uses of the genus Bletilla in traditional Chinese medicine: A phytochemical and pharmacological review

Jiang, Sai; Wang, Mengyun; Jiang, Lin; Xie, Qian; Yuan, Hanwen; Yang, Yupei; Zafar, Saima; Liu, Yang; Jian, Yuqing; Li, Bin; Wang, Wei

doi:10.1016/j.jep.2021.114263

Cited by 51 publications

(35 citation statements)

References 74 publications

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“…As the main traditional medicinal plant, B. striatai is the only original plant, B. ochracea and B. formosana are also used as local medications or substitutes [ 3 ]. Currently, the research of Bletilla mainly focuses on chemical components, pharmacological activities and reproductive techniques [ 4 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, approximately 211 compounds have been extracted from B. striata pseudobulbs, including glucosides, bibenzyls, phenanthrenes, quinones, stilbenes, triterpenoids, phenolics etc. [ 5 , 9 , 15 , 16 ]. Militarine (1,4-bis [4-(glucooxy) benzyl]-2-isobutyl malate (C 34 H 46 O 17 )) shows the highest content in the nonpolysaccharide fraction in B. striata [ 17 ], with content ranging from 1.45% to 9.28% [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Phenotype correlation analysis and excellent germplasm screening of herb Bletilla Rchb. f. based on comprehensive evaluation from thirty-three geographic populations

et al. 2022

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Background The Bletilla genus of Orchidaceae includes plants with great economic value, among which B. striata is the main traditional medicinal plant, and its pseudobulb, known as BaiJi, was first recorded in Shennong’s Classic of Materia Medica. However, there has been little systemic evaluation of the germplasm quality of Bletilla plants in China. In order to comprehensive evaluate the Bletilla resources in China and screen out the candidate phenotypic traits determining yield and/or quality of Bletilla, the variation of phenotypic indicators (pseudobulb, leaf, stem, inflorescence, flower) and active ingredients contents (polysaccharide, total phenolics and militarine) in different populations of B. striata and B. ochracea were investigated through 4 years’ common-garden experiment. Results There were abundant phenotypic variations and significant differences among different populations in the morphological phenotypes, pseudobulb weight and main active ingredient contents. AHBZ, HBLT and HBSN populations showed good prospects for industrial development, presenting higher quality in terms of yield and main active ingredient content. Pseudobulb yield, polysaccharide and total phenol content are positively correlated with phenotypic traits. Militarine content is negatively correlated with almost all indexes. Plant height, leaf width and stem diameter may be important indicators of potential excellent germplasms. Conclusions Bletilla is not strictly geoauthentic medicinal plants. B. ochracea could be accepted as an alternative resource to B. striata. The best harvest period of Bletilla is the third year after cultivation. Plant height, leaf width and stem diameter may be important indicators of potential excellent germplasms. These results provide important information required for the efficient screening and utilization of Bletilla germplasm resources.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenotype correlation analysis and excellent germplasm screening of herb Bletilla Rchb. f. based on comprehensive evaluation from thirty-three geographic populations

et al. 2022

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“…Rchb. f, named “Bai Ji”, is a traditional Chinese medicine, which are used for the treatment of several health disorders, including gastrointestinal disorders, ulcers, lung disorders, chapped skin, and traumatic bleeding ( He et al, 2017 ; Zhang et al, 2019 ; Liao et al, 2019 ; Wang et al, 2020 ; Hou et al, 2021 ; Wang et al, 2021 ; Jiang et al, 2021 ; Xu et al, 2021 ). As an Orchidaceae plant, it can biosynthesize many secondary stilbenes, such as bibenzyls, phenanthrenes, dihydrophenanthrenes, biphenanthrenes, dihydrophenanthrofurans, and phenanthrenequinones ( Sun et al, 2016 ; Jiang et al, 2019a ; Zhu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Bibenzyl Enantiomers From the Tubers of Bletilla striata

Jiang

Chen

et al. 2022

Front. Chem.

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Six new bibenzyls (three pairs of enantiomers), bletstrins D–F (1–3), were isolated from the ethyl acetate-soluble (EtOAc) extract of tubers of Bletilla striata (Thunb.) Rchb f. Their structures, including absolute configurations, were determined by 1D/2D NMR spectroscopy, optical rotation value, and experimental electronic circular dichroism (ECD) data analyses, respectively. Compounds 1–3 possess a hydroxyl-substituted chiral center on the aliphatic bibenzyl bridge, which represented the first examples of natural bibenzyl enantiomers from the genus of Bletilla. The antibacterial, antitumor necrosis factor (anti-TNF-α), and neuroprotective effects of the isolates have been evaluated. Compounds 3a and 3b were effective against three Gram-positive bacteria with minimum inhibitory concentrations (MICs) of 52–105 μg/ml. Compounds 2a and 2b exhibited significant inhibitory effects on TNF-α-mediated cytotoxicity in L929 cells with IC50 values of 25.7 ± 2.3 μM and 21.7 ± 1.7 μM, respectively. Subsequently, the possible anti-TNF-α mechanism of 2 was investigated by molecular docking simulation. Furthermore, the neuroprotective activities were tested on the H2O2-induced PC12 cell injury model, and compounds 2b, 3a, and 3b (10 μM) could obviously protect the cells with the cell viabilities of 57.86 ± 2.08%, 64.82 ± 2.84%, and 64.11 ± 2.52%, respectively.

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“…B. ochracea and B. formosana are also used as local medications or substitutes [3]. Currently, Bletilla research is focus mainly on chemical components, pharmacological activities and reproductive techniques, while there has been little systemic evaluation of the germplasm quality of Bletilla plants in China [4][5][6][7][8][9]. B. striata polysaccharide (BSP) is rich in the dried pseudobulb with content of 20-50% [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, approximately 211 compounds have been extracted from B. striata pseudobulbs, including glucosides, bibenzyls, phenanthrenes, quinones, stilbenes, triterpenoids, phenolics etc. [5,9,[15][16]. Militarine (1,4-bis [4-(glucooxy) benzyl]-2-isobutyl malate (C 34 H 46 O 17 )) shows the highest content in the nonpolysaccharide fraction in B. striata [17], with content ranging from 1.45% to 9.28% [18].…”

Section: Introductionmentioning

confidence: 99%

Phenotype - Chemotype Correlation of the Herb Bletilla Rchb. f. Based on a Comprehensive Evaluation of Thirty- Three Geographic Populations

Huang

Fang

Zhou

et al. 2021

Preprint

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Background The Bletilla genus of Orchidaceae includes plants with great economic value, among which B. striata is the main traditional medicinal plant, and its pseudobulb, known as BaiJi, was first recorded in Shennong's Classic of Materia Medica. However, there has been little systemic evaluation of the germplasm quality of Bletilla plants in China. In order to comprehensive evaluate the Bletilla resources in China and screen out the candidate phenotypic traits determining yield and/or quality of Bletilla, the variation of phenotypic indicators (pseudobulb, leaf, stem, inflorescence, flower) and active ingredients contents (polysaccharide, total phenolics and militarine) in different populations of B. striata and B. ochracea were investigated through 4 years' common-garden experiment. Results There were abundant phenotypic variations and significant differences among different populations in the morphological phenotypes, pseudobulb weight and main active ingredient contents. Five populations, including HNSZ, AHBZ, HBLT, HBSN and JSNJ, showed good prospects for industrial development, presenting higher quality in terms of yield and main active ingredient content. Pseudobulb yield, polysaccharide and total phenol content are positively correlated with phenotypic traits. Militarine content is negatively correlated with almost all indexes. Plant height, leaf width and stem diameter may be important indicators of potential excellent germplasms. Conclusions Bletilla is not strictly geoauthentic medicinal plants. B. ochracea could be accepted as an alternative resource to B. striata. The best harvest period of Bletilla is the third year after cultivation. Plant height, leaf width and stem diameter may be important indicators of potential excellent germplasms. These results provide important information required for the efficient screening and utilization of Bletilla germplasm resources.

show abstract

The medicinal uses of the genus Bletilla in traditional Chinese medicine: A phytochemical and pharmacological review

Cited by 51 publications

References 74 publications

Phenotype correlation analysis and excellent germplasm screening of herb Bletilla Rchb. f. based on comprehensive evaluation from thirty-three geographic populations

Phenotype correlation analysis and excellent germplasm screening of herb Bletilla Rchb. f. based on comprehensive evaluation from thirty-three geographic populations

Bioactive Bibenzyl Enantiomers From the Tubers of Bletilla striata

Phenotype - Chemotype Correlation of the Herb Bletilla Rchb. f. Based on a Comprehensive Evaluation of Thirty- Three Geographic Populations

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