The medicinal uses, toxicities and anti-inflammatory activity of Polyalthia species (Annonaceae)

Yao, Lui Jin; Jalil, Juriyati; Attiq, Ali; Hui, Chiew Chia; Zakaria, Nurul Aimi

doi:10.1016/j.jep.2018.10.001

Cited by 27 publications

(15 citation statements)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other major bioactive phytochemicals in Polyalthia species are flavonoids, lignans, sterols, organic acids, etc. [27,[38][39][40][41][42]. In fact, clerodane-type diterpenes may be one of the most well-studied and enrichedcompound in Polyalthia species, and the pharmacological and physiological functions of 16-hydroxycleroda-3,13-dien-15,16-olide (36 and/or 38, abbreviated CD or HCD in literatures) have been studied by several groups [24,[43][44][45][46][47].…”

Section: Phytochemical Constituents In Species Of Polyalthiamentioning

confidence: 99%

“…CD (38) has been determined as a new structural class of HMG-CoA reductase inhibitor [46] that alleviates adipogenesis in vitro and in vivo [47]. An FDA-approved drug, statin, a well-known inhibitor of HMG-CoA reductase, is now undergoing clinical trials for combination with standard chemotherapy or with other molecular-targeted drugs to improve cancer patients' treatment outcomes and overcome drug resistance [111].…”

Section: Anti-cancer Potential Of Polyalthia Genusmentioning

confidence: 99%

“…Furthermore, the pure components inside Polyalthia with pharmacological effects should be additionally examined to possibly find more effective substances. Certainly, for the known pure compounds, such as 16-hydroxycleroda-3,13-dien-16,15-olide (36) and/or 16α-hydroxycleroda-3,13-dien-16,15-olide (38), it should be worth further investigating in detail in vitro and in vivo mechanisms that can conceivably be used as drugs for chemoprevention.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

2021

View full text Add to dashboard Cite

Polyalthia belong to the Annonaceae family and are a type of evergreen tree distributed across many tropical and subtropical regions. Polyalthia species have been used long term as indigenous medicine to treat certain diseases, including fever, diabetes, infection, digestive disease, etc. Recent studies have demonstrated that not only crude extracts but also the isolated pure compounds exhibit various pharmacological activities, such as anti-oxidant, anti-microbial, anti-tumor, anti-cancer, etc. It is known that the initiation of cancer usually takes several years and is related to unhealthy lifestyle, as well as dietary and environmental factors, such as stress, toxins and smoking. In fact, natural or synthetic substances have been used as cancer chemoprevention to delay, impede, or even stop cancer growing. This review is an attempt to collect current available phytochemicals from Polyalthia species, which exhibit anti-cancer potentials for chemoprevention purposes, providing directions for further research on the interesting agents and possible clinical applications.

show abstract

Section: Phytochemical Constituents In Species Of Polyalthiamentioning

confidence: 99%

Section: Anti-cancer Potential Of Polyalthia Genusmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

2021

View full text Add to dashboard Cite

show abstract

“…Polyalthia longifolia belongs to the Annonaceae family and is widely distributed in India, Pakistan, and Sri Lanka which have been used as medications for thousand years 17 . Its traditional-medical indication has assessed in evidence-based approaches for decades and antibacterial, anticancer, and antiin ammatory activities have been con rmed 18 . 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) is one type diterpene isolated from P. longifolia which has reported tumoricidal activity in various cancers such as glioma, oral squamous cell carcinoma (OSCC), and renal cell carcinoma 19,20 .…”

Section: Introductionmentioning

confidence: 99%

Diterpene 16-hydroxycleroda-3,13-dien-15,16-olide emerges non-canonical autophagic cell death in doxorubicin-resistant lung cancer

Chiu¹,

Shen²,

Wu³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The antitumor activity of HCD has been reported in numerous types of cancers. Moreover, the antitumor of HCD could also be applied in non-small-cell lung cancer (NSCLC) cells and further act on doxorubicin-resistant (Dox-R) of NSCLC cells. The underlying anti-cancer mechanism of HCD on Dox-R versus Dox-sensitive (Dox-S) of A549 cells was under this investigation. Methods: Cytotoxicity of HCD against two cell lines (Dox-S and Dox-R) were determined via MTT assay, flow cytometry, and Western blot; and further examination of its anti-cancer efficacy in A549-bearing xenograft mice via orthotopic intratrachea (IT) inoculation. Result: Regardless sensitive and resistant to Dox, HCD could arrest both Dox-S and Dox-R cells at G 2 /M phase without altering the sub-G 1 cycle along with increasing cleaved-PARP. HCD downregulated the mTOR/Akt/PI3K-p85 and PI 3 K-ClassIII/Beclin-1 and upregulated p62/LC3-I/II expressions, further confirmed the cell autophagy after HCD-induced. Morphological observations of the mouse lung sections illustrated that fewer cancer cells accumulated around the trachea while there were less neoplastic activities found in HCD orthotopic treatment mice without liver, kidney and spleen toxicity. Conclusion: HCD exhibited the chemotherapeutic potential for lung cancer in Dox-resistant cells, suggesting natural autophagic inducer HCD provides a promising clue of new drug discovery and development for lung cancer therapy.

show abstract

“…Earlier reviews on the genus Polyalthia [3,4] and plant P. longifolia [1] summary the general phytochemistry and pharmacological activities of Polyalthia extracts. To our knowledge, there is no review on the therapeutic applications of chemical constituents of P. longifolia, till date.…”

mentioning

confidence: 99%

A Review on Therapeutic Benefits of Active Chemical Moieties Present in Polyalthia longifolia

Vishala¹,

Hieu²,

Killari³

et al. 2021

ijps

View full text Add to dashboard Cite

Vishala et al.: Chemistry and Pharmacology of Polyalthia longifoliaPolyalthia longifolia (Annonaceae family) is native to the drier areas of India and is locally called "Ashoka." It is also cultivated in Southeast Asia, Africa, Australia and New Zealand. Polyalthia longifolia is also known as Buddha tree, mast tree, cemetery tree, false Ashoka or green Champa. Generally, Polyalthia longifolia is viewed as a street tree because of its effectiveness in combating noise pollution. Macroscopically, the versatile Polyalthia longifolia can reach over 15.0 m high with symmetrical pyramidal growth and weeping pendulous branches. The term Polyalthia is derived from Greek roots, with "poly" meaning many and "althia" meaning cure, indicating that this plant has been used to treat various diseases/disorders. In traditional and indigenous systems of medicine, Polyalthia longifolia has been commonly used in the treatment of fever, helminthiasis, diabetes and various cardiac problems. Pharmacological investigations have shown that Polyalthia longifolia possesses significant biological and pharmacological activity, which may include antibacterial, antifungal, antitumor, anti-ulcer, antidiabetic and antioxidant properties. To date, more than 30 studies have analyzed extracts from bark, leaves, roots, seeds, etc. of the plant and reported a total of approximately 100 compounds, including steroids, flavonoids, clerodane diterpenes, cleroda-oic acids and alkaloids. In context of the broad medicinal potential of Polyalthia longifolia, this review compiles a detailed exploration of currently available knowledge of the phytochemical and their pharmacological properties of Polyalthia longifolia. Its potential applications in the treatment of various conditions are also discusseds.

show abstract

The medicinal uses, toxicities and anti-inflammatory activity of Polyalthia species (Annonaceae)

Cited by 27 publications

References 195 publications

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities

Diterpene 16-hydroxycleroda-3,13-dien-15,16-olide emerges non-canonical autophagic cell death in doxorubicin-resistant lung cancer

A Review on Therapeutic Benefits of Active Chemical Moieties Present in Polyalthia longifolia

Contact Info

Product

Resources

About