The Mediterranean Lecture: Wine and Thrombosis – From Epidemiology to Physiology and Back

Gaetano, Giovanni de; Castelnuovo, Augusto Di; Donati, Maria Benedetta; Iacoviello, Licia

doi:10.1159/000083847

Cited by 35 publications

(18 citation statements)

References 56 publications

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“…Moderate wine consumption (one to two glasses daily) has been associated with decreased cardiovascular mortality and decreased risk of heart disease in epidemiological studies and meta-analyses (de Gaetano et al 2003). These benefits have been attributed to increased antioxidant capacities, changes in lipid profiles, and anti-inflammatory effects (reviewed in Cordova et al 2005, Dohadwala andVita 2009).…”

Section: Cardiovascular Effectsmentioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

168

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Abstract:As indicated by epidemiological studies, regular and moderate wine consumption, particularly red wine, has been associated with health benefits. Clinical studies and work performed with animal models indicate that wine may protect against cardiovascular disease, atherosclerosis, hypertension, certain types of cancer, type 2 diabetes, neurological disorders, and metabolic syndrome. The mechanism of action has been attributed to antioxidant, lipid regulating, and anti-inflammatory effects. A variety of wine constituents have been studied in various disease models. Both the alcoholic and polyphenolic components of wine are believed to contribute to these beneficial effects. As wine is a complex mixture, it is likely that a multitude of chemical constituents, as well as their metabolites, work synergistically to impact human health. In sum, although wine drinking may be contraindicated in certain individuals, in healthy people, regular consumption of moderate amounts of wine may protect against certain chronic health conditions.

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Section: Cardiovascular Effectsmentioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

168

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“…The cardio-protective effect of most alcoholic beverages is probably due to ethanol-induced elevation of HDL and lowering of platelet aggregation, but the cardio-protective effect of (red) wine may be attributed at least in part to the antioxidant vaso-relaxant and antithrombotic properties of naturally occurring (polyphenolic) compounds [69]. Strong epidemiological evidence indicates that moderate consumption of wine (one to two drinks per day) is associated with a significant reduction of vascular events; however, definite proof could only be obtained by large long-term trials.…”

Section: Red Wine and Polyphenolsmentioning

confidence: 99%

“…People who are already regular lightmoderate wine consumers may be encouraged to continue, but the hazards of excess drinking should always be highlighted, and heavy drinkers should be encouraged to cut consumption to a moderate level [69]. Interestingly, a beneficial effect of red wine over white wine has been demonstrated in a recent human trial, where red wine consumption led to attenuated collagen induced platelet aggregation compared to subjects who consumed white wine [70].…”

Section: Red Wine and Polyphenolsmentioning

confidence: 99%

Review: Nutriceuticals as Antithrombotic Agents

Chakrabarti

Freedman

2010

Cardiovascular Therapeutics

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Thrombus formation in a disrupted endothelium is influenced not only by the platelet redox state and reactive oxygen and nitrogen species but also by the presence of endogenous or exogenous antioxidants. Thrombus formation in the stenotic arteries is triggered predominantly by attenuated shear stress. Superoxide and nitric oxide production, as well as their metabolism, potentially influence platelet activation and thrombosis. Antioxidant supplementation has not been generally associated with better cardiovascular outcome and is often compounded by bleeding and hemorrhagic stroke. Because of recent developments like the human genome project and personalized medicine, an emerging new area of nutrigenomics and nutraceuticals offers a scientific approach of diet‐based therapeutics applicable to a plethora of human diseases, including cardiovascular inflammation and thrombosis. Therefore, further mechanistic research using nutragenomics and nutraceuticals in the prevention and management of thrombosis offers great potential and may be effective in limiting the problems associated with antioxidant‐based therapeutics. In the present review, we have summarized the effect of dietary antioxidants in the modulation of platelet‐mediated thrombosis. In addition, therapeutic opportunities in the area of nutragenomics and nutraceuticals in vascular and nonvascular diseases are also discussed.

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“…Estudios realizados in vitro, han demostrado que una dosis baja de etanol (0,01-0,10%, v/v) aumenta la actividad fibrinolítica, la cual va acompañada de un aumento en la expresión del t-PA y u-PA [31][32][33] .…”

Section: Alcohol Y Fibrinolisisunclassified

“…vamente la fibrinolisis 31 . Recientemente, se ha reportado que quercetina inhibe la proliferación en cultivos de células endoteliales de origen microvascular 47 y la expresión de citocinas proinflamatorias en macrófagos estimulados con LPS (lipopolisacáridos) 48 .…”

Section: Tabla 1 Niveles De Compuestos Fenólicos En Vino Blanco Y Tintounclassified