The melanocyte lineage in development and disease

Mort, Richard L.; Jackson, Ian J.; Patton, E Elizabeth

doi:10.1242/dev.123729

Cited by 168 publications

(198 citation statements)

References 105 publications

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“…It is estimated that more than seventy thousand melanoma cases were diagnosed in 2014 in the United States (2) and is still rapidly increasing compared to any other solid tumors (3). Over the past years, some progress has been made in surgery removal, chemotherapy and radiotherapy (4,5). However, the incidence and mortality rate have been increasing for higher recurrence and metastasis.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

Ding

Hong

et al. 2016

BST

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

Ding

Hong

et al. 2016

BST

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“…Thus, the creation of mouse-human NC chimeras represents a novel experimental platform to investigate NC-associated human diseases under in vivo conditions. It will be particularly attractive to use this experimental platform to study NC-derived tumors (28,29). Because tumor formation is clonal, it should be possible to study initiation, progression, and manifestation of the tumors under in vivo conditions, even if donor cell contribution is low.…”

Section: Discussionmentioning

confidence: 99%

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos

Cohen

Wert

Goldmann

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The neural crest (NC) represents multipotent cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating embryo. The NC has major clinical relevance because it is involved in both inherited and acquired developmental abnormalities. The aim of this study was to establish an experimental platform that would allow for the integration of human NC cells (hNCCs) into the gastrulating mouse embryo. NCCs were derived from pluripotent mouse, rat, and human cells and microinjected into embryonic-day-8.5 embryos. To facilitate integration of the NCCs, we used recipient embryos that carried a c-Kit mutation (W sh /W sh ), which leads to a loss of melanoblasts and thus eliminates competition from the endogenous host cells. The donor NCCs migrated along the dorsolateral migration routes in the recipient embryos. Postnatal mice derived from injected embryos displayed pigmented hair, demonstrating differentiation of the NCCs into functional melanocytes. Although the contribution of human cells to pigmentation in the host was lower than that of mouse or rat donor cells, our results indicate that hNCCs, injected in utero, can integrate into the embryo and form mature functional cells in the animal. This mouse-human chimeric platform allows for a new approach to study NC development and diseases.human neural crest cells | chimera | embryonic stem cells | melanocytes

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“…An NCC origin for AML and LAM cells has been largely favored 14,15,17 because of their coexpression of melanocytic and smooth cell markers, two cell lineages known to arise either fully, in the case of melanocytes, 38 or partially, in the case of smooth muscle cells, 39 from NCCs. However, because TSC2 down-regulated all the NCC markers expressed by TSC2 À cells without inducing the expression of NCC precursor markers, our findings were inconsistent with AML arising from NCCs.…”

Section: Discussionmentioning

confidence: 99%

Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2− Tumor Related to Lymphangioleiomyomatosis

Yue

Pacheco

Cheng

et al. 2016

The American Journal of Pathology

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Angiomyolipoma (AML) is a tumor closely related to lymphangioleiomyomatosis (LAM). Both entities are characterized by the proliferation of smooth muscle actin and melanocytic glycoprotein 100 (recognized by antibody HMB-45)epositive spindle-shaped and epithelioid cells. AML and LAM are etiologically linked to mutations in the tsc2 and tsc1 genes in the case of LAM. These genes encode the proteins tuberous sclerosis complex (TSC)-1 and TSC2, which are directly involved in suppressing the mechanistic target of rapamycin cell growth signaling pathway. Although significant progress has been made in characterizing and pharmacologically slowing the progression of AML and LAM with rapamycin, our understanding of their pathogenesis lacks an identified cell of origin. We used an AML-derived cell line to determine whether TSC2 restitution brings about the cell type from which AML arises. We found that AML cells express lymphatic endothelial cell markers consistent with lymphatic endothelial cell precursors in vivo and in vitro. Moreover, on TSC2 correction, AML cells mature into adult lymphatic endothelial cells and have functional attributes characteristic of this cell lineage, suggesting a lymphatic endothelial cell of origin for AML. These effects are dependent on TSC2-mediated mechanistic target of rapamycin inactivation. Finally, we demonstrate the in vitro effectiveness of norcantharidin, a lymphangiogenesis inhibitor, as a potential co-adjuvant therapy in the treatment of AML. (Am J Pathol 2016 http://dx

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The melanocyte lineage in development and disease

Abstract: There was an error published in Development 142, 620-632.The affiliations were incorrectly linked to the second and third authors. The authors appear with their correct affiliations above.The authors apologise to readers for this mistake. 1387

Cited by 168 publications

References 105 publications

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

RETRACTED: Silence of MACC1 decreases cell migration and invasion in human malignant melanoma through inhibiting the EMT

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos

Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2− Tumor Related to Lymphangioleiomyomatosis

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