2014
DOI: 10.1016/j.ijdevneu.2014.09.001
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The melatonin analog 5‐MCA‐NAT increases endogenous dopamine levels by binding NRH:quinone reductase enzyme in the developing chick retina

Abstract: NRH:quinone reductase (QR2) is present in the retinas of embryonic and post-hatched (PH) chicks. 5-Methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) is a QR2 ligand that increases cAMP levels in developing retinas, but it does not affect cAMP levels in CHO-QR2 cells. The dopamine quinone reductase activity of QR2 retrieves dopamine, which increases cAMP levels in developing retinas. The objective of the present study was to investigate whether 5-MCA-NAT increases endogenous dopamine levels in retinas from ch… Show more

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Cited by 12 publications
(13 citation statements)
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“…Several physiological effects of melatonin such as inhibition of leukocyte adhesion to rat endothelial cell layers were mimicked by MT3 agonists (Lotufo et al, ). Similar observations were made for the expression of adhesion molecules by granulocytes (Cernysiov et al, ), the increase in dopamine levels in chick retina (Sampaio Lde et al, ) and the reduction of intraocular pressure (IOP) in rabbits (Alarma‐Estrany et al, ). However, it has been questioned whether the functional effects of MCA‐NAT are indeed mediated by QR2, as the lack of QR2 did not prevent the MCA‐NAT‐induced reduction on IOP, and overexpression of QR2 did not promote receptor‐like responses (Vincent et al, ).…”
Section: Introductionsupporting
confidence: 61%
“…Several physiological effects of melatonin such as inhibition of leukocyte adhesion to rat endothelial cell layers were mimicked by MT3 agonists (Lotufo et al, ). Similar observations were made for the expression of adhesion molecules by granulocytes (Cernysiov et al, ), the increase in dopamine levels in chick retina (Sampaio Lde et al, ) and the reduction of intraocular pressure (IOP) in rabbits (Alarma‐Estrany et al, ). However, it has been questioned whether the functional effects of MCA‐NAT are indeed mediated by QR2, as the lack of QR2 did not prevent the MCA‐NAT‐induced reduction on IOP, and overexpression of QR2 did not promote receptor‐like responses (Vincent et al, ).…”
Section: Introductionsupporting
confidence: 61%
“…These compounds act as negative allosteric modulators thus inhibiting the enzyme, which plays a role in reduction-oxidation (REDOX) mechanisms occurring between quinones, semiquinones, and hydroquinones. It is not clear whether QR2 has a relevant role in melatonin physiology although the data on the 5-MCA-NAT-QR2 interaction suggest that dopamine may indirectly mediate actions resulting from melatonin regulation of QR2 activity; in fact, melatonin inhibits dopamine release from amacrine cells (Lavoie et al, 2013;Sampaio Lde et al, 2014;Wiechmann and Sherry, 2013).…”
Section: Melatonin Receptors and Signalling Pathwaysmentioning
confidence: 99%
“…The enzyme, human quinone reductase 2 (22), seems to be allosterically regulated by melatonin and other endogenous compounds (e.g. N-acetylserotonin); however, its role as potential mediator of melatonin physiological effects is under discussion (23)(24)(25).…”
Section: Introductionmentioning
confidence: 99%