The Melatonin Receptor CAND2/PMTR1 Is Involved in the Regulation of Mitochondrial Gene Expression under Photooxidative Stress

Bychkov, Ivan A.; Kudryakova, N. V.; Шугаев, А. Г.; Кузнецов, Вл. В.; Kusnetsov, V. V.

doi:10.1134/s1607672922010021

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Since the first report, proteins with similarity to CAND2/PMTR1 have been identified in Panax notoginseng [ 119 ], Nicotiana benthamiana [ 120 ], Medicago sativa [ 121 ], Zea mays [ 122 ], and Gossypium hirsutum [ 123 ]. In CAND2/PMTR1 knock-out mutants or overexpressed plants, stomatal closure [ 21 , 124 ], immunity [ 119 , 120 ], osmotic stress tolerance [ 125 ], salt and osmotic stress tolerance [ 121 , 122 ] and mitochondrial gene expression [ 126 ] were affected, supporting the idea that the CAND2/PMTR1 is the actual phytomelatonin receptor. However, some researchers questioned the conclusion that CAND2/PMTR1 is a receptor for phytomelatonin because they obtained different results in Arabidopsis [ 127 ], whereas CAND2/PMTR1 was first reported to be the receptor for phytomelatonin [ 21 ].…”

Section: Receptorsmentioning

confidence: 95%

“…MAPK activation occurs independently of GPA1 [ 119 ], while stomatal closure is dependent on GPA1 [ 119 ]. The mechanisms that regulate ABA biosynthesis [ 22 ], salicylic acid accumulation [ 120 ], expression of PR genes [ 120 ], mitochondrial gene expression [ 126 ], ROS scavenging activity [ 125 ], and tolerance to salt [ 123 ], drought [ 122 ], and osmotic [ 125 ] stress under the regulation of CAND2/PMTR1 are not yet fully understood. Dephosphorylation of CAND2/PMTR1 abolishes the binding of melatonin to CAND2/PMTR1 [ 128 ].…”

Section: Figurementioning

confidence: 99%

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Have All of the Phytohormonal Properties of Melatonin Been Verified?

Park

2024

IJMS

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Melatonin is a ubiquitous regulator in plants and performs a variety of physiological roles, including resistance to abiotic stress, regulation of growth and development, and enhancement of plant immunity. Melatonin exhibits the characteristics of a phytohormone with its pleiotropic effects, biosynthesis, conjugation, catabolism, effective concentration, and the shape and location of its dose–response curves. In addition, CAND2/PMTR1, a phytomelatonin receptor candidate belonging to the G protein-coupled receptors (GPCRs), supports the concept of melatonin as a phytohormone. However, the biochemistry of plant melatonin receptors needs to be further characterized. In particular, some of the experimental findings to date cannot be explained by known GPCR signaling mechanisms, so further studies are needed to explore the possibility of novel signaling mechanisms.

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Section: Receptorsmentioning

confidence: 95%

Section: Figurementioning

confidence: 99%

Have All of the Phytohormonal Properties of Melatonin Been Verified?

Park

2024

IJMS

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“…reviewed ( Zhang et al., 2022 ) that the first MT receptor in Arabidopsis was the candidate G protein-coupled receptor 2 (CAND2), a membrane protein that readily binds to MT ( Wei et al., 2018 ). Research has demonstrated that the introduction of melatonin from an external source can induce the upregulation of the genes RPOTm and RPOTmp through the CAND2 receptor and its G protein alpha subunit (GP A1) ( Bychkov et al., 2022 ). Arabidopsis Cand2/pmrt1, which is located at the plasma membrane, is known to interact with GPA1 and control stomatal movement by means of the NADPH oxidase-mediated reactive oxygen species (ROS) signaling pathway ( Li et al., 2020 ).…”

Section: Plant Growth Promotersmentioning

confidence: 99%

The role of indole derivative in the growth of plants: A review

et al. 2023

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Indole compounds with their unique properties of mimicking peptide structures and reversible binding to enzymes are of great exploitative value in the regulation of plant growth. They stimulate root and fruit formation and activate the plant’s immune system against biotic and abiotic factors harmful to the plant. Analysis of target recognition, receptor recognition, key activation sites and activation mechanisms of indoles in plant to enhance crop growth or disease resistance is a crucial step for further developing compounds as plant growth regulators and immune inducers. Therefore, this review focused on the mechanism of action of indoles in regulating plant growth and enhancing plant resistance to biotic and abiotic stresses.

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“…The first phytomelatonin receptor in Arabidopsis thaliana , candidate G-protein coupled receptor 2 ( CAND2 ), a membrane protein that binds readily with melatonin, was identified in 2018 [ 12 ]. Treatment with exogenous melatonin at a 50 μM concentration upregulated the RNA polymerase genes RPOTm and RPOTmp by promoting the CAND2 receptor and heterotrimeric G protein α subunit ( GPA1 ) coupled to CAND2 [ 13 ]. In Arabidopsis , Cand2/pmrt1 is located on the plasma membrane (PM), interacts with GPA1 , and regulates stomatal movement via the reactive oxygen species (ROS) signaling pathway mediated by NADPH oxidase [ 14 ].…”

Section: Melatonin Signaling In Plantsmentioning

confidence: 99%

Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance

Zhang

Gao

et al. 2022

Cells

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Plant growth and development exhibit plasticity, and plants can adapt to environmental changes and stress. Various phytohormones interact synergistically or antagonistically to regulate these responses. Melatonin and indole-3-acetic acid (IAA) are widespread across plant kingdom. Melatonin, an important member of the neuroendocrine immune regulatory network, can confer autoimmunity and protect against viral invasion. Melatonin functions as a plant growth regulator and biostimulant, with an important role in enhancing plant stress tolerance. IAA has a highly complex stress response mechanism, which participates in a series of stress induced physiological changes. This article reviews studies on the signaling pathways of melatonin and IAA, focusing on specific regulatory mechanisms. We discuss how these hormones coordinate plant growth and development and stress responses. Furthermore, the interactions between melatonin and IAA and their upstream and downstream transcriptional regulation are discussed from the perspective of modulating plant development and stress adaptation. The reviewed studies suggest that, at low concentrations, melatonin promotes IAA synthesis, whereas at high levels it reduces IAA levels. Similarly to IAA, melatonin promotes plant growth and development. IAA suppresses the melatonin induced inhibition of germination. IAA signaling plays an important role in plant growth and development, whereas melatonin signaling plays an important role in stress responses.

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The Melatonin Receptor CAND2/PMTR1 Is Involved in the Regulation of Mitochondrial Gene Expression under Photooxidative Stress

Cited by 9 publications

References 18 publications

Have All of the Phytohormonal Properties of Melatonin Been Verified?

Have All of the Phytohormonal Properties of Melatonin Been Verified?

The role of indole derivative in the growth of plants: A review

Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance

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