The menace of obesity to depression and anxiety prevalence

Fulton, Stephanie; Décarie-Spain, Léa; Fioramonti, Xavier; Guiard, Bruno P.; Nakajima, Shingo

doi:10.1016/j.tem.2021.10.005

Cited by 201 publications

(132 citation statements)

References 164 publications

(202 reference statements)

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“…This study did not include anxiety and depressive mood in our analysis, and we believe that this comorbidity factor would weaken the overall statistical power if controlled for as a covariate. Especially when anxiety and depression themselves are highly correlated with obesity ( 49 ), it is a very dangerous move to try to eliminate the major factors, which may be the abnormal phenotypes shared by anxiety and depression with obesity. As our previous study explored ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

How Impulsiveness Influences Obesity: The Mediating Effect of Resting-State Brain Activity in the dlPFC

Han

Zhang

et al. 2022

Front. Psychiatry

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Impulsiveness is a stable personal characteristic that contributes to obesity and may interact with it. Specifically, obesity is caused by unrestrained impulse eating that is not consciously controlled and leads to a hormonal imbalance that also can impair impulse control. However, the mechanism of this relationship is unclear. In our study, 35 obese individuals (body mass index, BMI > 28) were recruited and matched with 31 healthy controls (BMI < 24) in age and education level. All the participants underwent a resting-state fMRI and completed the Barratt Impulsiveness Scale-11. The results showed that patients with obesity had a significantly lower fractional amplitude of low-frequency fluctuations (fALFF) in the bilateral dorsolateral prefrontal cortex (dlPFC) and higher fALFF in the left fusiform cortex. In addition, non-planning impulsiveness was positively correlated with BMI. Importantly, we found that the right dlPFC completely mediated the relationship between non-planning impulsiveness and BMI. Our findings suggest that impulsivity is statistically more likely to precede obesity than to precede impulsivity and contributes to obesity by downregulating spontaneous activity in the dlPFC. This suggests that the dlPFC, which is associated with executive control, may be able a potential target for treating obesity.

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Section: Discussionmentioning

confidence: 99%

How Impulsiveness Influences Obesity: The Mediating Effect of Resting-State Brain Activity in the dlPFC

Han

Zhang

et al. 2022

Front. Psychiatry

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“…Recent results suggest that central leptin resistance seems to play a role in MDD, which is known to progress in old age ( 31 , 64 ). In general, leptin's involvement in the pathophysiology of depression is quite well documented: it decreases anxiety- and despair- behavior in mice ( 65 – 68 ), most likely by acting on mesolimbic neurons ( 69 , 70 ). Furthermore, it has been shown to enhance SSRI-action ( 71 , 72 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been shown to enhance SSRI-action ( 71 , 72 ). A leptin analog, metreleptin, even exhibited swift antidepressant action in depressed anorexia-nervosa patients, which is associated with low leptin levels ( 65 , 73 ). In a recent study, leptin was present in a proteomic cluster which was significantly associated with depressive symptoms, along with C-reactive protein (CRP) ( 74 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

et al. 2022

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BackgroundGhrelin and the adipokines leptin and adiponectin have been suggested to be involved in mood and anxiety regulation and to be altered in affective disorders. However, studies investigating the association between ghrelin, leptin and adiponectin and depressive symptomatology are scarce but might contribute to a better understanding of their involvement in mood regulation. We thus aimed investigating the association between depressive symptomatology and total ghrelin as well as leptin and adiponectin serum levels in a large population-based sample.MethodsTotal serum ghrelin, adiponectin and leptin levels were determined in 1666 subjects of a population-based cross-sectional study (“LIFE”). The Center for Epidemiological Studies Depression Scale (CES-D) and the Inventory of Depressive Symptoms – Self Rating (IDS-SR) were administered. Multiple linear regression analyses were conducted to examine the association between total serum ghrelin, leptin and adiponectin and the intensity of depressive symptoms.ResultsIn the total sample (n = 1,092), neither ghrelin nor leptin or adiponectin serum levels showed a significant association with CES-D or IDS-SR sum scores (N = 1,092) or in depressed/non-depressed subjects. Leptin serum levels showed a significantly positive association with IDS-SR sum scores in elderly men (≥60 years; β = 0.122, 95% CI: 0.009; 0.236; p = 0.035).ConclusionOur study suggests that peripheral levels of ghrelin and adipokines in a cross-sectional study design might not be sufficient to measure their involvement in depression, suggesting that associations are more complex and multi-layered.

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“…Other correlates increasing the risk of the cooccurrence of obesity and depression concern physical health. Several studies have shown that both conditions are associated with biological and medical factors [ 24 , 25 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Psychological Profiles of Treatment-Seeking Adults with Overweight and Obesity: A Cluster Analysis Approach

Plasonja

Brytek-Matera

Décamps

2022

JCM

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Background: Overweight and obesity are associated with depression and well-being. Some psychological characteristics play a role in explaining well-being and depression in obesity and in identifying specific patient profiles. However, subtyping individuals with overweight/obesity based on variables like self-esteem or stress has not often been done. Therefore, our objective was to explore the psychological profiles of treatment-seeking individuals overweight or with obesity and to compare their depression and well-being. Methods: Data regarding eating self-efficacy, well-being, depression, physical hunger, self-esteem, body satisfaction and perceived stress in individuals with overweight/obesity were collected from the ESTEAM cohort. Hierarchical cluster analysis and mean comparisons were performed on female (n = 1427) and male samples (n = 310). Results: Three psychological profiles were identified in both samples. The “High psychological concerns” profile and the “Low psychological concerns” profile were identical in both samples. The third profile, “Bodily concerns”, differed by sex and was characterized by appearance dissatisfaction for women and by appearance and eating concerns for men. The ”Low psychological concerns” profile presented the highest well-being and the lowest depression scores in both samples. Discussion: The findings support the hypothesis of the heterogeneity of individuals with overweight and obesity and suggest sex-related therapeutic approaches.

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The menace of obesity to depression and anxiety prevalence

Cited by 201 publications

References 164 publications

How Impulsiveness Influences Obesity: The Mediating Effect of Resting-State Brain Activity in the dlPFC

How Impulsiveness Influences Obesity: The Mediating Effect of Resting-State Brain Activity in the dlPFC

Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample

Psychological Profiles of Treatment-Seeking Adults with Overweight and Obesity: A Cluster Analysis Approach

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