The Meningococcal Carrier-Rate

Fraser, P. K.; Bailey, GD; Abbott, Jane; Gill, Joseph B.; Walker, D.J.C.

doi:10.1016/s0140-6736(73)90541-2

Cited by 46 publications

(22 citation statements)

References 17 publications

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“…The carriage rates reported here are somewhat lower than those in previous studies, in which rates varying from Ͻ16% to over 70% have been reported among military recruits (1,15,28,30). These previous studies were performed mainly on unvaccinated populations, however.…”

Section: Discussioncontrasting

confidence: 84%

Genotypic and Phenotypic Characterization of Carriage and Invasive Disease Isolates of Neisseria meningitidis in Finland

et al. 2012

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Section: Discussioncontrasting

confidence: 84%

Genotypic and Phenotypic Characterization of Carriage and Invasive Disease Isolates of Neisseria meningitidis in Finland

et al. 2012

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“…Variations undoubtedly occurred due to agressiveness of the swabber, logistics of delivery of specimens or subsidiary experiments (note Table 7 and 11-14). There has been extensive discussion about the relative importance of high or low carriage rates (Fraser et al 1973;Wenzel et al 1973). Dudley & Brennan (1934) showed that high and persistent carriage rates of meningococci were not associated with cases of meningococcal meningitis, and numerous papers have shown that the carrier rate bears no direct relationship to the incidence of clinical disease (Greenwood, Hassan-King & Whittle, 1978).…”

Section: Discussionmentioning

confidence: 99%

Carriage ofNeisseria meningitidis: investigations in a military establishment

et al. 1988

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SUMMARYA prevalence study of personnel on a Royal Naval Air Station revealed that 23-0 % of 2479 personnel were carrying a meningococcus. Selected groups of personnel were subsequently swabbed monthly for a year. We have shown that it is only by repeated swabbing and the use of optimal methods including enrichment media that one can have a hope of identifying the 'true' carriage rate. A presumed virulent strain of Neisseria meningitidis B 15 P 1. 16 was repeatedly isolated from three personnel who remained well, as did their colleagues both at their work place and socially. The study served to emphasize our lack of knowledge of the virulence factors associated with N. meningitidis.

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“…A cluster of Discussion subjects from a single troop of military recruits were colonized at some time during their 30-week training period, apparently High levels of meningococcal acquisition and carriage have been demonstrated to occur commonly within semiclosed enviby a single meningococcal strain, which was characterized as X:4:NST. Although subtyping by serologic methods could not ronments, such as military camps [2,31] evidence of a specific immune response to the class 1 protein of each strain acquired during the study.…”

Section: Effect Of Carriage On Immune Response To Individual Meningocmentioning

confidence: 95%

“…However, the majority of isolates that have previously been obtained from such studies have not been eas-X:4:P1.22,27a strain. Thus, it would appear that the major contribution to the bactericidal activity of sera from each of ily characterized by standard serologic typing methods, since they are frequently not typeable and/or subtypeable [2,31,32]. the subjects was subtype-specific.…”

Section: Effect Of Carriage On Immune Response To Individual Meningocmentioning

confidence: 99%

“…Closed or semiclosed commuvaccines [7]. However such vaccines, based solely on capsular nities, such as military recruit camps, often have even higher polysaccharide, provide only limited protection against serocarriage rates of §50% [2]. High rates of carriage are also groups A and C and offer no protection against serogroup B observed in family and other close contacts of meningococcal strains [8], which are the predominant cause of meningococcal disease.…”

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confidence: 99%

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Dynamics of Carriage of Neisseria meningitidis in a Group of Military Recruits: Subtype Stability and Specificity of the Immune Response following Colonization

Jones¹,

Christodoulides²,

Brooks³

et al. 1998

Journal of Infectious Diseases

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Meningococcal carriage and the immune response to colonization were studied in a group of military recruits undergoing basic training. Subtyping by determination of the class 1 protein sequence clearly differentiated between strains and demonstrated the dynamics of carriage and transmission. Expression of class 1 protein by each strain remained stable during prolonged carriage by different subjects. Following colonization, a marked increase in serum bactericidal response occurred, which was specific for the subtype of the acquired strain and was associated with an increase in reactivity by Western blot to the homologous class 1 protein. Subjects colonized by multiple strains showed evidence of a specific immune response to the class 1 protein of each strain acquired. The subtype specificity of the bactericidal response to meningococci and the stability of expression of the class 1 protein have important implications for the design of vaccines for prevention of serogroup B meningococcal disease.

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The Meningococcal Carrier-Rate

Cited by 46 publications

References 17 publications

Genotypic and Phenotypic Characterization of Carriage and Invasive Disease Isolates of Neisseria meningitidis in Finland

Genotypic and Phenotypic Characterization of Carriage and Invasive Disease Isolates of Neisseria meningitidis in Finland

Carriage ofNeisseria meningitidis: investigations in a military establishment

Dynamics of Carriage of Neisseria meningitidis in a Group of Military Recruits: Subtype Stability and Specificity of the Immune Response following Colonization

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