“…Although it has been shown that cognitive impairments are associated with alterations in specific brain regions (Liang & Carlson, 2020; Reas et al., 2018; Roldán‐Tapia et al., 2012), a detailed knowledge of the ultrastructural changes in such areas is lacking. Numerous studies have evaluated brain processing of cognitive functions including memory speed, decision‐making, attention, and perception during aging using functional magnetic resonance imaging (Branch et al., 2019; Löckenhoff & Rutt, 2017; Löckenhoff et al., 2020; Tausen et al., 2020). These and other morphological studies indicate structural modifications such as decrease of synapse and spine densities, decrease in grey matter and volume as well as microcolumn disorganization in cognitive regions of the brain (Alexander et al., 2020; Bonifazi et al., 2018; Guerra‐Gomes et al., 2018; Peters & Kemper, 2012).…”