The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma

Abstract

In this work, we investigated the activity of the key NAD(P)-dependent dehydrogenases associated with macrophage tumors in mice with Ehrlich ascites carcinoma. It was shown that cancer grow is associated with the development of conditions in macrophages leading to a decrease in the substrate flow intensity in the tricarboxylic acid cycle, deceleration of oxidative deamination of L-glutamate, NADP regeneration, and a decrease in the antioxidant defense efficiency. There results are consistent with our recent concept on the nonspecific metabolic reaction of cells to extreme exposures.

Features and applications of Ehrlich tumor model in cancer studies: a literature review

“…Inzhevatkin et al reported the suppression of metabolic processes of macrophages that were associated with tumors during tumor growth. Neutrophils are another important cell population in tumor development ( 32 ). AEC plays a paradoxical dual role in these cells, in which neutrophils are responsible for controlling tumor development in susceptible animals (e.g., Swiss mice), but in mice that are resistant to tumor development [e.g., CAF1 (BALB/c A/J) F1 mice], neutrophils improve tumor growth ( 33 ).…”