1998
DOI: 10.1251/bpo8
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The metabolic inhibition model which predicts the intestinal absorbability and Metabolizability of drug: Theory and experiment

Abstract: The intestinal absorption of analgesic peptides (leucine enkephalin and kyotorphin) and modified peptides in rat were studied. Although these peptides were not absorbed, the absorbability (absorption clearance) of these peptides were increased in the presence of peptidase inhibitors. In order to kinetically analyze these phenomena, we proposed the metabolic inhibition model, which incorporated the metabolic clearance (metabolizability) with the absorption clearance. Metabolic activity was determined with intes… Show more

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