The Metabolic Role of Ketogenic Diets in Treating Epilepsy

Kaleem, Imdad; Abualait, Turki; Al-Ghannam, Ziyad T.; Bashir, Shahab; Farrukh, Anum; Khattak, Sahir Hameed; Albaradie, Raidah; Bashir, Shahid

doi:10.3390/nu14235074

Cited by 15 publications

(16 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The KD is a well-known dietary regimen that can reduce symptoms of epilepsy and weight gain [ 7 , 8 ]. In the current study, body weight gain was significantly lower in KD-fed mice than in the DM group.…”

Section: Discussionmentioning

confidence: 99%

Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes

Park,

Yang

2024

PLoS ONE

View full text Add to dashboard Cite

Diabetes is often associated with reduced muscle mass and function. The ketogenic diet (KD) may improve muscle mass and function via the induction of nutritional ketosis. To test whether the KD is able to preserve muscle mass and strength in a mouse model of type 2 diabetes (T2DM), C57BL/6J mice were assigned to lean control, diabetes control, and KD groups. The mice were fed a standard diet (10% kcal from fat) or a high-fat diet (HFD) (60% kcal from fat). The diabetic condition was induced by a single injection of streptozotocin (STZ; 100 mg/kg) and nicotinamide (NAM; 120 mg/kg) into HFD-fed mice. After 8-week HFD feeding, the KD (90% kcal from fat) was fed to the KD group for the following 6 weeks. After the 14-week experimental period, an oral glucose tolerance test and grip strength test were conducted. Type 2 diabetic condition induced by HFD feeding and STZ/NAM injection resulted in reduced muscle mass and grip strength, and smaller muscle fiber areas. The KD nutritional intervention improved these effects. Additionally, the KD altered the gene expression of nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome- and endoplasmic reticulum (ER) stress-related markers in the muscles of diabetic mice. Collectively, KD improved muscle mass and function with alterations in NLRP3 inflammasome and ER stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes

Park,

Yang

2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…To cope with this lethal issue, the use of advanced technology by combining various fields and methodologies is of great benefit, in terms of loss reduction [17,19,[60][61][62][63][64]. In this regard, specifically, it has been demonstrated that a number of classes of antimicrobial nanoparticles (NPs) and nano sized carriers for antibiotic delivery are efficient methods for the treatment of infectious or fatal diseases, including those that are resistant to antibiotics, in vitro as well as in plant or animal models [54,65].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>

Yu,

Alkasir,

Farrukh

et al. 2024

Pol. J. Environ. Stud.

View full text Add to dashboard Cite

Nanotechnology offers exciting prospects against infectious agents, particularly multidrug resistance bacteria (MDR), which is the roaring concern of this era. Zinc oxide nanoparticles (ZnO-Nps) efficiently deliver therapeutic agents into living systems due to their biocompatibility and bioactivity, which make them highly effective against infectious pathogens. The present investigation was designed to investigate the impact of the ZnO-Nps in combination with the Piperacillin-Tazobactam (TZP) drug against MDR. TZP are beta-lactam antibiotics highly effective against Gram-positive and Gram-negative

show abstract

“…In recent years, the KD has been increasingly utilised as an adjunctive treatment for epileptic disorders. Numerous studies have examined the antiepileptic potential of this diet, delving extensively into the mechanisms by which nutritional ketosis produces its therapeutic effect [ 24 , 93 , 102 , 103 ]. The primary hypothesised mechanisms underlying the antiepileptic effect of the KD are summarised in Figure 4 .…”

Section: Kd Versus Cns Disordersmentioning

confidence: 99%

Dietary Influence on Drug Efficacy: A Comprehensive Review of Ketogenic Diet–Pharmacotherapy Interactions

Marinescu,

Apetroaei,

Nedea

et al. 2024

Nutrients

View full text Add to dashboard Cite

It is widely acknowledged that the ketogenic diet (KD) has positive physiological effects as well as therapeutic benefits, particularly in the treatment of chronic diseases. Maintaining nutritional ketosis is of utmost importance in the KD, as it provides numerous health advantages such as an enhanced lipid profile, heightened insulin sensitivity, decreased blood glucose levels, and the modulation of diverse neurotransmitters. Nevertheless, the integration of the KD with pharmacotherapeutic regimens necessitates careful consideration. Due to changes in their absorption, distribution, metabolism, or elimination, the KD can impact the pharmacokinetics of various medications, including anti-diabetic, anti-epileptic, and cardiovascular drugs. Furthermore, the KD, which is characterised by the intake of meals rich in fats, has the potential to impact the pharmacokinetics of specific medications with high lipophilicity, hence enhancing their absorption and bioavailability. However, the pharmacodynamic aspects of the KD, in conjunction with various pharmaceutical interventions, can provide either advantageous or detrimental synergistic outcomes. Therefore, it is important to consider the pharmacokinetic and pharmacodynamic interactions that may arise between the KD and various drugs. This assessment is essential not only for ensuring patients’ compliance with treatment but also for optimising the overall therapeutic outcome, particularly by mitigating adverse reactions. This highlights the significance and necessity of tailoring pharmacological and dietetic therapies in order to enhance the effectiveness and safety of this comprehensive approach to managing chronic diseases.

show abstract

The Metabolic Role of Ketogenic Diets in Treating Epilepsy

Cited by 15 publications

References 99 publications

Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes

Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes

Synergistic Antibacterial Potential of Zno-Nps with Different Antibiotics against Multidrug-Resistant <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>

Dietary Influence on Drug Efficacy: A Comprehensive Review of Ketogenic Diet–Pharmacotherapy Interactions

Contact Info

Product

Resources

About