The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study

Bonora, Enzo; Targher, Giovanni; Formentini, G.; Calcaterra, Francesco; Lombardi, Sara; Marini, F; Zenari, Luciano; Saggiani, F.; Poli, Maurizio; Perbellini, S.; Raffaelli, Andrea; Gemma, Lee W.; Santi, Lorenza; Bonadonna, Riccardo C.; Muggeo, Michele

doi:10.1046/j.1464-5491.2003.01068.x

Cited by 253 publications

(165 citation statements)

References 24 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…Our finding that metabolic syndrome predicted CVD death is in agreement with results from previous studies in non-diabetic [27][28][29] and type 2 diabetic subjects [30,31]. In the study of Bonora et al [30], no sex-related differences were found in the prediction of CVD among type 2 diabetic patients.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

et al. 2005

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

“…In the study of Bonora et al [30], no sex-related differences were found in the prediction of CVD among type 2 diabetic patients. Our finding that among non-diabetic subjects metabolic syndrome was a stronger predictor of CVD mortality in women than in men is of interest.…”

Section: Discussionmentioning

confidence: 81%

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

et al. 2005

View full text Add to dashboard Cite

“…It is well known that type 2 diabetes is accompanied by an increased risk of CVD independently of conventional cardiovascular risk factors such as hypertension or dyslipidemia [14,15]. Furthermore, the relative risk for CVD in type 2 diabetic patients with metabolic syndrome diagnosed by NCEP-ATP III definition is greater than in those without metabolic syndrome, and its risk is modified by the number of components of metabolic syndrome [16][17][18]. However, whether the new definition of metabolic syndrome in which central obesity is mandatory is a better predictor of CVD than the individual components of metabolic syndrome in type 2 diabetic patients has not yet been clarified.…”

mentioning

confidence: 99%

Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

et al. 2007

View full text Add to dashboard Cite

Abstract. Metabolic syndrome has been revealed to be a major risk factor for cardiovascular disease (CVD) and early mortality in non-diabetic and diabetic patients. In 2005, the International Diabetes Federation (IDF) and the Examination Committee of Criteria for Diagnosis of Metabolic Syndrome in Japan published new definitions of metabolic syndrome in which central obesity was an indispensable factor. However, the significance of this new definition to CVD in type 2 diabetes has not yet been clarified. A cross-sectional study was conducted with 294 Japanese type 2 diabetic patients without known cardiovascular disease to evaluate the association between metabolic syndrome defined by this new definition and carotid atherosclerosis, and the significance of central obesity for the prediction of the development of carotid atherosclerosis. In a multivariate regression analysis, metabolic syndrome but not central obesity was significantly associated with carotid intima-media thickness (IMT) independent of known cardiovascular risk factors (p<0.05). In addition, whereas carotid IMT was significantly increased according to the increase in the number of components of metabolic syndrome, it was not significantly different between the groups with the same number of components of metabolic syndrome with or without central obesity. These findings suggest that the prediction of the development of carotid atherosclerosis in Japanese type 2 diabetic patients could be improved by the assessment of aggregation of components of metabolic syndrome rather than with or without metabolic syndrome by this new definition.

show abstract

“…Type 2 diabetes represents a paradigmatic condition in which the metabolic syndrome is highly prevalent (27,28) and often precedes the onset of hyperglycemia. Furthermore, insulin resistance and the metabolic syndrome predict atherosclerosis in type 2 diabetic patients (12,27).…”

mentioning

confidence: 99%

The Metabolic Syndrome Is a Risk Indicator of Microvascular and Macrovascular Complications in Diabetes

2006

Diabetes Care

166

View full text Add to dashboard Cite

Results from Metascreen, a multicenter diabetes clinic-based survey THE METASCREEN WRITING COMMITTEE* OBJECTIVE -We aimed at assessing the degree of association and the predictive power of the metabolic syndrome with regard to clinically detectable complications in patients with diabetes.RESEARCH DESIGN AND METHODS -Metascreen is a cross-sectional survey of metabolic syndrome and clinically detected diabetes complications performed in 8,497 patients (7,859 with type 2 diabetes and 638 with type 1 diabetes) randomly chosen in 176 diabetes outpatient clinics throughout Italy. The metabolic syndrome was defined according to either the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) or the International Diabetes Federation (IDF) diagnostic criteria. Multivariate analyses of the association(s) between either AHA/NHLBI or IDF metabolic syndrome and clinical complications were performed. Receiver-operator characteristic (ROC) curves were constructed to compare the predictive power of the two sets of diagnostic criteria of the metabolic syndrome.RESULTS -Either definition of the metabolic syndrome was an independent statistical indicator of the presence of nephropathy and neuropathy (P Ͻ 0.02-0.01) in type 1 diabetes and of all complications (P Ͻ 0.0001), including cardiovascular disease and retinopathy, in type 2 diabetes. For each complication, the ROC curves based on either AHA/NHLBI or IDF metabolic syndrome were similar to each other and to the ROC curves constructed with all continuous traits compounding the metabolic syndrome.CONCLUSIONS -The metabolic syndrome, defined according to AHA/NHLBI or IDF diagnostic criteria, is an independent clinical indicator and may be involved in the pathogenesis of both macro-and microvascular complications of diabetes. Diabetes Care

show abstract

The Metabolic Syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study

Abstract: In Type 2 diabetes, the presence of the Metabolic Syndrome is associated with an almost 5-fold increase in CVD risk.

Cited by 253 publications

References 24 publications

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

Is Central Obesity a Good Predictor of Carotid Atherosclerosis in Japanese Type 2 Diabetes with Metabolic Syndrome?

The Metabolic Syndrome Is a Risk Indicator of Microvascular and Macrovascular Complications in Diabetes

Contact Info

Product

Resources

About