The Metabolic Syndrome is Associated with More Aggressive Prostate Cancer

Abstract

Purpose: The aim of this study was to analyze any association between the metabolic syndrome (MetS) and risk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materials and Methods: 50 patients with MetS and 50 patients without MetS who undervent radical prostatectomy (RP) were included in the study. Age at biopsy, height, weight, digital rectal examination (DRE), pre-biopsy PSA levels, prostate volume, histopathologic diagnosis after surgery and gleason scores were collected data from all patients. Histologic material obtained at biopsy was given a Gleason score; tumours with a Gleason score ≥7 were considered high grade and <7 were considered low grade. Results: The mean age at the time of biopsy was 63.7±5.94 in patients with MetS and 61.6±6.14 in patients without MetS. Men with MetS had significantly lower PSA levels (p=0.01) (7.21±2.74 and 8.81±2.72, respectively). Also, the men with MetS had higher RP tumor grade (p=0.04). Conclusions: Men with MetS undergoing RP have lower PSA levels and have significantly higher grade PCa. We must be careful for screening PCa in patients with MetS. Although the patients had lower PSA levels, they may have high grade disease.

Human Kallikrein-2, Prostate Specific Antigen and Free-Prostate Specific Antigen in Combination to Discriminate Prostate Cancer from Benign Diseases in Syrian Patients

“…PSA levels influenced by many factors like age, race, the Metabolic Syndrome or even Body Mass Index (BMI) and alcohol consumption (Chiu et al, 2011;Bashir et al, 2014;Daniyal et al, 2014;Ozbek et al, 2014;Woo et al, 2014). But the most important disadvantage of the PSA test is its low specificity which means that a high percentage of the men are negative on initial biopsy (Jansen et al, 2009).…”

Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

“…A deeper research into the factors that differ significantly across these continents may answer the questions regarding its incidence and causative factors. The foremost risk factors that may underlie these regional/ethnic differences could be endocrine variations, genetic polymorphisms (ZeiglerJohnson et al, 2002) altered hormonal status (Garfinkel, 1986), socioeconomic status (Nomura and Kolonel, 1991) and obesity and diet (Stephen and Brady, 2005;Girling et al, 2007) Diet, disturbed glucose metabolism, and metabolic syndrome are extremely interesting factors for in depth exploration in relation to the risk of prostate cancer (Long et al, 2012;McGrowder et al, 2012;Tewari et al, 2012;Ozbek et al, 2014, Pandeya et al 2014 In an earlier study, we presented that body mass index and waist to hip ratio were significantly higher in prostate cancer in 1 , Singh Rajender 2 *…”

Serum lipids might improve prostate-specific antigen sensitivity in patients undergoing transrectal ultrasonography-guided biopsy for suspected prostate cancer: A pilot study

“…A handful of studies have shown a close link between obesity, serum lipids and prostate cancer [3,4]. Elevated triglycerides (TGs) and low highdensity lipoprotein (HDL) levels were significantly associated with high-grade prostate cancer, albeit this relationship was not consistent between reports [5][6][7][8]. Moreover, low HDL was associated with adverse pathological findings after radical prostatectomy (RP) [9].…”