The metabolic syndrome is associated with decelerated cognitive decline in the oldest old

Berg, Esther van den; Biessels, Geert-Jan; Craen, Anton J. M. de; Gussekloo, Jacobijn; Westendorp, Rudi G.J.

doi:10.1212/01.wnl.0000271381.30143.75

Cited by 172 publications

(139 citation statements)

References 34 publications

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“…Thus, these results support that women with MetS exhibit an increased incidence of cognitive decline compared with men with MetS. Another study that focused on the oldest adults (≥ 85 years) failed to reveal a link between MetS and cognitive decline, but this result might be related to survival bias [5].…”

Section: Discussionsupporting

confidence: 56%

“…MetS is known to affect cognition, regardless of the mechanism, and evidence suggests that MetS, as a whole, is associated with declining cognitive function [4]. Although several studies have investigated the association between MetS and the risk of cognitive decline [5][6][7][8] in recent years, the effect of MetS on the rate of cognitive decline remains controversial [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Syndrome Predicts Cognitive Decline in Community-Dwelling Elderly People: A 10-Year Cohort Study

Chang¹,

Yen²

2018

Neuropsychiatry

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Background:Cognitive function has been reported to predict subsequent disability and mortality in elderly people. This study aimed to explore whether metabolic syndrome (MetS) resulted in cognitive decline in community-dwelling elderly people or not, accounting for depression and other risk factors during a long-term follow-up period. Methods and Findings:A community-based cohort of 300 older adults was followed up for 10 years. Relationships among MetS, depressive symptoms, and consequent cognitive dysfunction were explored using a logistic regression. The presence of MetS at the baseline visit was associated with a 2.7-fold increase in the risk of cognitive decline after 10 years, and depressive symptoms were associated with a 2.4-fold increase in the risk of cognitive decline in the community-dwelling elderly people. Conclusions:The long-term outcomes of MetS are associated with a significantly increased risk of cognitive decline among community-dwelling elderly people.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome Predicts Cognitive Decline in Community-Dwelling Elderly People: A 10-Year Cohort Study

Chang¹,

Yen²

2018

Neuropsychiatry

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“…Of the studies having examined whole samples without gender stratification, a number of prospective studies found no significant associations with T-C, LDL-C, HDL-C, and TG (Reitz et al, 2005;Reitz et al, 2008;Solfrizzi et al, 2004;Teunissen et al, 2003;van den Berg et al, 2007). Solomon et al reported positive associations between midlife (but not late-life) T-C and cognitive decline in episodic memory and fluency (Solomon et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Gender-specific associations between lipids and cognitive decline in the elderly

Ancelin

Ripoche

Dupuy

et al. 2014

European Neuropsychopharmacology

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The aim of this study was to examine the associations between serum lipid levels and cognitive function in a community-based sample of non-demented subjects aged 65 years and over.Participants were 2737 men and 4118 women from a population-based cohort recruited from three French cities. Visual memory, verbal fluency, psychomotor speed, and executive abilities were evaluated at baseline, and after 2, 4, and 7 years of follow-up. Lipid levels were evaluated at baseline. Multiadjusted Cox models stratified by gender were adjusted for sociodemographic and lifestyle characteristics, mental and physical health, and genetic vulnerability to dyslipidemia (apolipoprotein E and A, and cholesteryl ester transfer protein) and taking into account baseline vascular pathologies. In men, a hypercholesterolemic pattern in late-life (high total cholesterol (T-C), low HDL-C, high LDL-C levels) was associated with a 25 to 50% increased risk of decline over 7 years in psychomotor speed, executive abilities, and verbal fluency. Specific associations with low T-C and low LDL-C levels were also observed which may depend on genetic vulnerability to dyslipidemia (related to apolipoprotein A5 and cholesteryl exchange transfer protein). In contrast, in women, a 30% higher rate of decline was found in psychomotor speed with high HDL-C levels and in executive abilities with low levels of LDL-C and triglycerides, in interaction with hormonal treatment. For men and women, vascular pathologies only slightly outweighed the risk related to lipids. This suggests a complex gender-specific pattern of cognitive decline involving genetic vulnerability in men and hormonal status in women.

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“…And this non-association remained regardless of the presence of ApoE e4 allele. However, previous studies reported that there was a significant association between MS and cognitive decline in the elderly (Dik et al, 2007;Komulainen et al, 2007;Van den Berg et al, 2007;Yaffe et al, 2007). It is possible that due to difference of the research design, different results may be obtained.…”

Section: Discussionmentioning

confidence: 94%

Relationship between the diagnostic components of metabolic syndrome (MS) and cognition by ApoE genotype in the elderly

Lee

Jang

Chung

et al. 2010

Archives of Gerontology and Geriatrics

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The metabolic syndrome is associated with decelerated cognitive decline in the oldest old

Abstract: The association between the metabolic syndrome and accelerated cognitive decline, which has been reported in persons up to age 75, is not evident in a population of the oldest old. The concept of the metabolic syndrome may be less valid in this age group.

Cited by 172 publications

References 34 publications

Metabolic Syndrome Predicts Cognitive Decline in Community-Dwelling Elderly People: A 10-Year Cohort Study

Metabolic Syndrome Predicts Cognitive Decline in Community-Dwelling Elderly People: A 10-Year Cohort Study

Gender-specific associations between lipids and cognitive decline in the elderly

Relationship between the diagnostic components of metabolic syndrome (MS) and cognition by ApoE genotype in the elderly

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