The metabolic syndrome is not associated with homocysteinemia: The Persian Gulf Healthy Heart Study

Nabipour, Iraj; Ebrahimi, Aziz; Jafari, Seyed Mojtaba; Vahdat, Katayoun; Assadi, Majid; Movahed, Ali; Moradhaseli, Farzad; Obeidi, Narges; Sanjdideh, Zahra

doi:10.1007/bf03346476

Cited by 22 publications

(20 citation statements)

References 25 publications

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“…Likewise, Hcy was positively associated with waist circumference, BMI, blood pressure, LDL-C, and triglycerides, but inversely associated with HDL in a Chinese sample of 1680 adults [49]. On the other hand, there are published reports where authors did not find associations [50] or observed associations with few components of MetS [51]. A lack of association of hyperhomocysteinemia with insulin resistance is consistent with other reports [52,53].…”

Section: Discussionsupporting

confidence: 80%

High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

Yakub

Schulze

Khatry³

et al. 2014

Nutrients

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Little attention has been given to the association of plasma homocysteine (Hcy) and metabolic syndrome (MetS) in children. We have evaluated the risk of MetS with plasma Hcy in a cohort of 6 to 8 year old rural Nepalese children, born to mothers who had participated in an antenatal micronutrient supplementation trial. We assessed Hcy in plasma from a random selection of n = 1000 children and determined the relationship of elevated Hcy (>12.0 μmol/L) to MetS (defined as the presence of any three of the following: abdominal adiposity (waist circumference ≥ 85th percentile of the study population), high plasma glucose (≥85th percentile), high systolic or diastolic blood pressure (≥90th percentile of reference population), triglyceride ≥ 1.7 mmol/L and high density lipoprotein < 0.9 mmol/L.) and its components. There was an increased risk of low high-density lipoproteins (HDL), [odds ratios (OR) = 1.77, 95% confidence intervals (CI) = 1.08–2.88; p = 0.020], high blood pressure [OR = 1.60, 95% CI = 1.10–2.46; p = 0.015] and high body mass index (BMI) [OR = 1.98, 95% CI = 1.33–2.96; p = 0.001] with elevated Hcy. We observed an increased risk of MetS (OR = 1.75, 95% CI = 1.06–2.90; p = 0.029) with elevated Hcy in age and gender-adjusted logistic regression models. High plasma Hcy is associated with increased risk of MetS and may have implications for chronic disease later in life.

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Section: Discussionsupporting

confidence: 80%

High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

Yakub

Schulze

Khatry³

et al. 2014

Nutrients

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“…age, enzyme deficiencies and mutations, vitamin deficiencies, disease, and drugs) for developing hyperhomocysteinemia, the metabolic syndrome has been recently reported to be associated with increased plasma homocysteine concentrations [23,24,25]. In contrast with the results reported in some previous studies indicating that the metabolic syndrome or its components could increase homocysteine concentrations [23,24,25], a lack of a correlation between metabolic syndrome components and increased homocysteine concentrations was observed in other studies [26,27,28]. Since there is no consistent evidence to demonstrate the association between plasma homocysteine and the metabolic syndrome, further study is thus warranted.…”

Section: Introductioncontrasting

confidence: 54%

“…In agreement with some previous studies [23,24,25], the results for our control and pooled, but not case, participants supported the implication that the metabolic syndrome and its components are associated with increased plasma homocysteine concentrations. However, other studies did not support this implication [26,27,28]. …”

Section: Discussionmentioning

confidence: 44%

The Metabolic Syndrome Is Associated with an Increased Risk of Colorectal Polyps Independent of Plasma Homocysteine

et al. 2014

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Background/Aims: The links between the metabolic syndrome and homocysteine in relation to the risk of colorectal polyps are not understood. The purpose of this study was to investigate the association between the metabolic syndrome and homocysteine and further analyze the relationship between these two factors and the risk of colorectal polyps. Methods: This was a case-control study. A total of 135 participants with colorectal polyps (cases) and 110 participants without polyps (controls) were recruited. Results: There were 59 participants with the metabolic syndrome in the case group and 36 participants with the metabolic syndrome in the control group. The metabolic syndrome and its individual components, except for serum triglycerides, and homocysteine were associated with the risk of colorectal polyps. When the association of the metabolic syndrome and homocysteine with the risk of colorectal polyps was simultaneously considered, the association between homocysteine and the risk of colorectal polyps disappeared, but waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol, and the metabolic syndrome itself were still significant risk factors for the development of colorectal polyps. Conclusion: Although the metabolic syndrome and plasma homocysteine were individually related to the risk of colorectal polyps, the metabolic syndrome was a major contributing factor in relation to the risk of colorectal polyps independent of plasma homocysteine.

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“…Nabipour et al reported significantly higher homocysteine levels in subjects with high blood pressure 20. Vayá et al however found no statistically significant association ( p = 0.008) between hyperhomocysteinaemia and hypertension ( p = 0.229) 15…”

Section: Introductionmentioning

confidence: 98%

Association of homocysteinaemia with hyperglycaemia, dyslipidaemia, hypertension and obesity : cardiovascular topic

Sengwayo¹,

Moraba²,

Motaung³

2013

CVJA

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AimHyperhomocysteinaemia and the metabolic syndrome are associated with increased cardiovascular risk. We investigated whether there is a link between the metabolic syndrome or its components and homocysteine levels in a population without cardiovascular disease.MethodsFrom the population sample of 382 participants (286 females and 96 males) we isolated those reflecting the metabolic syndrome and determined their homocysteine levels. We then evaluated the association of homocysteine with hyperglycaemia, hypertriglyceridaemia, hypercholesterolaemia, hypertension and obesity, using a significance level of p = 0.05. Enzymatic methods were used for all biochemical parameters.ResultsWe found the statistical relationship between homocysteine and the metabolic syndrome as follows: hyperglycaemia (p = 0.175), hypertriglyceridaemia (p = 0.442), hypercholesterolaemia (p = 0.480), obesity (p = 0.080); and hypertension: systolic pressure (p = 0.002) and diastolic pressure (p = 0.033).ConclusionWe found no statistically significant association between baseline plasma homocysteine levels and the metabolic syndrome, except for hypertension.

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The metabolic syndrome is not associated with homocysteinemia: The Persian Gulf Healthy Heart Study

Abstract: There was no association between the metabolic syndrome using NCEP-ATPIII criteria and homocysteinemia in this study. These data refute the hypothesis that homocysteine levels are influenced by the metabolic syndrome, at least in general healthy population.

Cited by 22 publications

References 25 publications

High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

The Metabolic Syndrome Is Associated with an Increased Risk of Colorectal Polyps Independent of Plasma Homocysteine

Association of homocysteinaemia with hyperglycaemia, dyslipidaemia, hypertension and obesity : cardiovascular topic

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