The Metabolism and Excretion of Curcumin (1,7-Bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the Rat

Holder, Gerald M.; Plummer, John L.; Ryan, A. J.

doi:10.3109/00498257809069589

Cited by 310 publications

(226 citation statements)

References 10 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…Most of the drug was metabolized, however, again suggesting poor absorption and rapid metabolism. Later, Holder et al [151] administered deuterium-and tritium-labeled curcumin orally and intraperitoneally to rats and, like Wahlstrom and Blennow, found that most of it was excreted in the feces. When they administered curcumin intravenously and intraperitoneally to cannulated rats, the curcumin was excreted in the bile.…”

mentioning

confidence: 99%

Curcumin as “Curecumin”: From kitchen to clinic

Goel

Kunnumakkara

Aggarwal

2008

Biochemical Pharmacology

1,942

1,290

View full text Add to dashboard Cite

mentioning

confidence: 99%

Curcumin as “Curecumin”: From kitchen to clinic

Goel

Kunnumakkara

Aggarwal

2008

Biochemical Pharmacology

1,942

1,290

View full text Add to dashboard Cite

“…However, serum‐containing curcumin application resulted in opposite, antiangiogenic effects 34. In addition, either oral consumption or intraperitoneal injection of curcumin resulted in ≈75% excretion, which suggested low absorption by the gastrointestinal tract 35, 36. Given the limitations with existing small molecules, CEP03 may be an attractive alternative for translational application.…”

Section: Discussionmentioning

confidence: 99%

Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease

Hou

Yang

Tang

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundCEP (ω‐[2‐carboxyethyl]pyrrole) protein adducts are the end products of lipid oxidation associated with inflammation and have been implicated in the induction of angiogenesis in pathological conditions such as tissue ischemia. We synthesized small molecules derived from CEP protein adducts and evaluated the angiogenic effect of the CEP analog CEP03 in the setting of peripheral arterial disease.Methods and ResultsThe angiogenic effect of CEP03 was assessed by in vitro analysis of primary human microvascular endothelial cell proliferation and tubelike formation in Matrigel (Corning). In the presence of CEP03, proliferation of endothelial cells in vitro increased by 27±18% under hypoxic (1% O2) conditions, reaching similar levels to that of VEGFA (vascular endothelial growth factor A) stimulation (22±10%), relative to the vehicle control treatment. A similar effect of CEP03 was demonstrated in the increased number of tubelike branches in Matrigel, reaching >70% induction in hypoxia, compared with the vehicle control. The therapeutic potential of CEP03 was further evaluated in a mouse model of peripheral arterial disease by quantification of blood perfusion recovery and capillary density. In the ischemic hind limb, treatment of CEP03 encapsulated within Matrigel significantly enhanced blood perfusion by 2‐fold after 14 days compared with those treated with Matrigel alone. Moreover, these results concurred with histological finding that treatment of CEP03 in Matrigel resulted in a significant increase in microvessel density compared with Matrigel alone.ConclusionsOur data suggest that CEP03 has a profound positive effect on angiogenesis and neovessel formation and thus has therapeutic potential for treatment of peripheral arterial disease.

show abstract

“…Tetrahydrocurcumin was identified as one of the major colorless metabolites of curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione) by Holder in 1978(Holder et al 1978. Tetrahydrocurcumin is useful as a colorless additive to food and cosmetics.…”

Section: Tetrahydrocurcuminmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

Kukongviriyapan

Apaijit

Kukongviriyapan

2016

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and nephropathy, all of which could be attributable to dysfunctional endothelial and smooth muscle cells. Cd toxicity is correlated with increased reactive oxygen formation and depletion of antioxidants, resulting in an oxidative stress. Chelation of Cd has proved useful in the removal of the Cd burden. However, several chelating agents cause side effects in clinical usage. Recent studies have shown that the antioxidant compounds curcumin and tetrahydrocurcumin can alleviate vascular dysfunction and high blood pressure caused by Cd toxicity. In chronic Cd exposure, these antioxidants protect vascular endothelium by increasing nitric oxide (NO•) bioavailability and improving vascular function. Antioxidant activity against Cd intoxication results directly and/or indirectly through free radical scavenging, metal chelation, enhanced expression of the antioxidant defense system, regulation of inflammatory enzymes, increase in NO• bioavailability, and reduction of gastrointestinal absorption and tissue Cd accumulation. This review summarizes current knowledge of Cd-induced oxidative stress and cardiovascular dysfunction and a possible protective effect conferred by the antioxidants curcumin and tetrahydrocurcumin.

show abstract

The Metabolism and Excretion of Curcumin (1,7-Bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the Rat

Cited by 310 publications

References 10 publications

Curcumin as “Curecumin”: From kitchen to clinic

Curcumin as “Curecumin”: From kitchen to clinic

Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease

Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin

Contact Info

Product

Resources

About