The Metabolism and Functions of Histamine

Histamine Release and Endotoxin Shock in the Primate*

“…Similar decreases have been reported in the dog administered endotoxin (22) and in various forms of shock in man and animals (39)(40)(41). Histamine may possibly be released from the bound form in whole blood to the circulating form in plasma (25,42), and from tissue such as muscle (43) or lung (44), or from various other sources (37).…”

“…Previous work in dogs (19) has indicated that the progressive increase of the histamine: histidine ratio is related to the relative rates of formation, conversion and destruction of the two components in question. It is possible that a rise in plasma histamine has resulted because of the marked decrease in the numbers of circulating platelets and white blood cells (37,38). Similar decreases have been reported in the dog administered endotoxin (22) and in various forms of shock in man and animals (39)(40)(41).…”

Comparative Studies of Two Models of Allergic Respiratory Disease

“…Blood histamine increase as a result of in vitro antigenic chal lenge of circulating leukocytes from some allergic human subjects (12,13) or following anaphylaxis in passively sensitized dogs has been shown (2). Histamine release studies using the leukocytes of either passively sensitized dogs or passively sensitized monkeys showed no detectable release of histamine nor did the circulating histamine levels increase following aerosol challenge in either species of recipient.…”

Histidinemia Produced in the Rat by Treatment with Nitromethane

“…1.22). The deamination process has been recognized as the principal pathway of histidine metabolism (13) and the decarboxylation process is only a minor one (1). Humans with an inborn error of metabolism, histidinemia, in which histidase is deficient in the liver and skin, showed high concentrations of histidine and imidazole compounds in the plasma and tissues (2,9).…”