THE METABOLISM OF 5‐HYDROXYTRYPTAMINE AND β‐PHENYL‐ETHYLAMINE IN PERFUSED RAT LUNG AND <i>IN VITRO</i>

Bakhle, Y.S.; Youdim, Moussa B. H.

doi:10.1111/j.1476-5381.1979.tb17343.x

Cited by 33 publications

(10 citation statements)

References 22 publications

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“…The IC50 values for (-)-deprenyl ranged from 5 x 10-9M to 5 x 10-8M. These results are similar to the inhibitory potencies of (-)-deprenyl for MAO-B in other tissues such as liver (17), human platelet (18), brain (19), and lung (20).…”

supporting

confidence: 67%

Isolated Chromaffin Cells from Adrenal Medulla Contain Primarily Monoamine Oxidase B

Youdim¹,

Banerjee²,

Pollard³

1984

Science

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Cultured chromaffin cells from bovine adrenal medulla were found to contain primarily the B form of monoamine oxidase. This monoamine oxidase B enzyme was somewhat distinct from B enzymes from other sources, in that noradrenaline was a much poorer substrate than serotonin. Nonetheless, studies with selective inhibitors of the A form (clorgyline) and the B form [(-)-deprenyl] confirmed that chromaffin cell monoamine oxidase was the B form. The observation that chromaffin cell monoamine oxidase has poor affinity for catecholamines is consistent with physiological needs that require the cell to synthesize and store large amounts of catecholamines.

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supporting

confidence: 67%

Isolated Chromaffin Cells from Adrenal Medulla Contain Primarily Monoamine Oxidase B

Youdim¹,

Banerjee²,

Pollard³

1984

Science

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“…The difficulty arises from the additional and often rate-controlling step involved in perfused lung, the uptake of substrate into the cell. This uptake is rate-limiting in lungs from male rats (Junod, 1972;Bakhle & Youdim, 1979) and as a result the metabolism of 5-HT in perfused lungs is less than that expected from the properties of MAO in cell-free preparations. In our present experiments with perfused lung, we had expected metabolism to reflect the results obtained with homogenates, i.e.…”

Section: Discussionmentioning

confidence: 99%

Effects of oestrous cycle and exogenous ovarian steroids on 5‐hydroxytryptamine metabolism in rat lung.

Bakhle¹,

Ben-Harari²

1979

The Journal of Physiology

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SUMMARY1. The metabolism of 5-hydroxytryptamine (5-HT) in homogenates of lung and in perfused isolated lungs, was measured, using [14C]5-HT, over the 4-day oestrous cycle in rats.2. In lung homogenates, 5-HT metabolism (reflecting monoamine oxidase (MAO) activity) was greater during met-oestrus than during the rest of the cycle.3. In homogenates, the apparent Km for MAO activity was lowest during metoestrus whereas the, Vmax value was highest during di-oestrus.4. In perfused lungs, 5-HT metabolism and uptake was greater during pro-oestrus than during met-oestrus.5. In lung homogenates prepared from female rats treated with 17fl-oestradiol or progesterone for 8 days, the metabolism of 5-HT was increased.6. We conclude that although the lung is not usually considered a target organ for ovarian hormones, its metabolic activity is affected by changes in the levels of endogenous or exogenous ovarian steroids, an effect comparable with those already observed in uterus, ovary and other more commonly accepted target organs.

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“…Pre-exposure ofrats to cigarette smoke for 1 hr either once or daily during 10 consecutive days did not affect the metabolism of 5-hydroxytryptamine (5-HT) in isolated perfused lung (62). However, there is evidence that cigarette smoke may change 5-HT metabolism.…”

Section: Effect Of Cigarette Smoking On Serotonin (5-ht) Metabolism Imentioning

confidence: 92%

Effects of cigarette smoking on metabolic events in the lung.

Kitamura¹

1987

Environ Health Perspect

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Nicotine and cigarette smoke extract show acute physiological effects: increasing tracheal pressure (PTR), pulmonary artery pressure (PPA), systemic blood pressure (PyT), and left atrium pressure (PLA); and decreasing cardiac output (4AORTA) and blood flow to the left lower lobe (1L). In addition, cigarette smoking induces bronchoconstriction, thus decreasing peak flow, FVC, and FEVY.o in healthy subjects. It has also been demonstrated that cigarette smoking caused temporary slowing of mucociliary clearance in the lung and that cigarette smoke increases the activity of aryl hydrocarbon hydroxylase which metabolizes benzo [a]pyrene. We demonstrated that serum angiotensin I converting enzyme (ACE) activity showed a significant increase immediately after smoking and returned to the control level 20 min after smoking. We also demonstrated that plasma histamine levels showed a marked decrease after smoldng. Furthermore, the effects of cigarette smoke and related substances on prostaglandin, thromboxane, testosterone, cyclic nucleotides metabolism, and protein synthesis were also investigated.

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THE METABOLISM OF 5‐HYDROXYTRYPTAMINE AND β‐PHENYL‐ETHYLAMINE IN PERFUSED RAT LUNG AND IN VITRO

Cited by 33 publications

References 22 publications

Isolated Chromaffin Cells from Adrenal Medulla Contain Primarily Monoamine Oxidase B

Isolated Chromaffin Cells from Adrenal Medulla Contain Primarily Monoamine Oxidase B

Effects of oestrous cycle and exogenous ovarian steroids on 5‐hydroxytryptamine metabolism in rat lung.

Effects of cigarette smoking on metabolic events in the lung.

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