The metabolism of chlorobiphenyls — A review

Sundström, Gerdt; Hutzinger, O.; Safe, S.

doi:10.1016/0045-6535(76)90002-3

Cited by 192 publications

(66 citation statements)

References 90 publications

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“…It is a major component of Aroclor 1254 (6.2%) and Aroclor 1260 (10.6%) mixtures. Due to the high resistance of this molecule to metabolic and microbial breakdown (Sundstrom et al, 1976), it is readily bio-accumulated and appears predominant in marine and freshwater biota as confirmed also by our data where PCB-153 was the principal contributor to total PCBs in all samplings. Generally, liver distribution in fish is depleted of the lower chlorinated congeners (PCB-28 and PCB-52), possibly as a result of their metabolic degradation (Garcia et al, 2000).…”

Section: Discussionsupporting

confidence: 71%

Polychlorinated biphenyls and antioxidant enzymes in liver ofCyprinus carpiofrom Lake Trasimeno

Elia

Galarini

Dörr

et al. 2005

Italian Journal of Zoology

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Polychlorinated biphenyl (PCB) congeners and selected biochemical parameters (total glutathione, glutathione-S-transferase, glutathione peroxidase, catalase, glutathione reductase, glyoxalase I, glyoxalase II were measured in carp liver of both sexes collected from Lake Trasimeno during the spawning and postspawning periods. The most abundant congeners found were PCB-138, PCB-153 and PCB-180, even if all PCB congeners investigated were recorded in low amounts. No significant variations in congener concentrations in relation to sex and sampling periods were observed in carp liver. Among the biochemical parameters investigated, total glutathione, glutathione S-transferase, glyoxalase II and catalase, showed differences according to sex, and thus the variations in antioxidant response of carp seem to be linked more to biological status, than to the presence of PCBs congeners in liver of the same specimens.

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Section: Discussionsupporting

confidence: 71%

Polychlorinated biphenyls and antioxidant enzymes in liver ofCyprinus carpiofrom Lake Trasimeno

Elia

Galarini

Dörr

et al. 2005

Italian Journal of Zoology

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“…Cumulative PCB exposure before birth was used to categorize exposure, to focus primarily on the potential fetotoxic effects of the more highly chlorinated PCBs such as Aroclor 1254, whose metabolism following exposure is minimal. 9 Maternal risk factors influencing birthweights are known to include maternal age, parity, ethnicity, social class, tobacco use, underlying medical conditions, maternal height, and previous history of low birthweight. '0 While we were able to adjust for the effects of the first four of these factors, we had no information on the latter four and could not account for them in our analysis.…”

Section: Discussionmentioning

confidence: 99%

Polychlorinated biphenyls: influence on birthweight and gestation.

Taylor¹,

Lawrence²,

Hwang³

et al. 1984

Am J Public Health

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Fifty-one infants born to women employed at two capacitor manufacturing facilities with a history of high exposure to polychlorinated biphenyls (PCBs) had a mean birthweight of 153 grams less than that of 337 infants born to women who had worked in low-exposure areas (90 per cent confidence interval, -286 to -20 g); mean gestational age was 6.6 days shorter in the high-exposure infants (90 per cent CI, -10.3 to -2.9 days). After adjusting for gestational age, the difference in birthweight was markedly reduced, indicating that the observed reduction in birthweight was due mainly to shortening of gestational age in the high-exposure group. (Am J

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“…The vast majority of PCBs in the environment are derived from commercial mixtures (e.g., Aroclors) which contain 60 to 80 different congeners (24). Bacteria able to degrade PCBs are relatively common; however, in most cases, these organisms have a narrow substrate specificity which allows them to degrade only a small number of lightly chlorinated PCBs (1,3,7,10,16,26,28). Such strains are of limited usefulness for bioremediation as they are unable to degrade many of the congeners found in commercial PCB mixtures.…”

mentioning

confidence: 99%

Nucleotide sequencing and transcriptional mapping of the genes encoding biphenyl dioxygenase, a multicomponent polychlorinated-biphenyl-degrading enzyme in Pseudomonas strain LB400

1992

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The DNA region encoding biphenyl dioxygenase, the first enzyme in the biphenyl-polychlorinated biphenyl degradation pathway of Pseudomonas species strain LB400, was sequenced. Six open reading frames were identified, four of which are homologous to the components of toluene dioxygenase from Pseudomonas putida Fl and have been named bphA, bphE, bphF, and bphG. From this comparison, biphenyl dioxygenase was found to be a multicomponent enzyme containing a two-subunit iron-sulfur protein, a ferredoxin, and a reductase.Comparison of the large subunit of the iron-sulfur protein and the ferredoxin with other multicomponent dioxygenases identified amino acid sequences similar to Rieske iron-sulfur proteins for binding a cluster. Sequences have also been identified in the reductase component that match the consensus sequence for FAD or NAD binding. Transcription of the biphenyl dioxygenase region was examined, and three transcription initiation sites were identified. Transcription initiating at the site furthest upstream is greatly increased when the LB400 cells are grown on biphenyl as the sole carbon source.

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The metabolism of chlorobiphenyls — A review

Cited by 192 publications

References 90 publications

Polychlorinated biphenyls and antioxidant enzymes in liver ofCyprinus carpiofrom Lake Trasimeno

Polychlorinated biphenyls and antioxidant enzymes in liver ofCyprinus carpiofrom Lake Trasimeno

Polychlorinated biphenyls: influence on birthweight and gestation.

Nucleotide sequencing and transcriptional mapping of the genes encoding biphenyl dioxygenase, a multicomponent polychlorinated-biphenyl-degrading enzyme in Pseudomonas strain LB400

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