1958
DOI: 10.1016/0006-3002(58)90524-9
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The metabolism of cortisol and progesterone by cultured uterine fibroblasts, strain U12-705

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Cited by 48 publications
(9 citation statements)
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“…Sweat et al in 1958 and Berliner, Swim, and Dougherty in 1960 studied the metabolism of progesterone, cortisol, and corticosterone by cultured human fibroblasts (3,4), thus demonstrating the feasibility of using the cell culture technique for the study of steroid metabolism. We wished to apply the technique of cell culture to the diagnosis of genetic disorders of steroid metabolism utilizing fibroblasts and amniotic fluid cells in culture.…”
Section: Introductionmentioning
confidence: 99%
“…Sweat et al in 1958 and Berliner, Swim, and Dougherty in 1960 studied the metabolism of progesterone, cortisol, and corticosterone by cultured human fibroblasts (3,4), thus demonstrating the feasibility of using the cell culture technique for the study of steroid metabolism. We wished to apply the technique of cell culture to the diagnosis of genetic disorders of steroid metabolism utilizing fibroblasts and amniotic fluid cells in culture.…”
Section: Introductionmentioning
confidence: 99%
“…In vertebrate species, 20a-HSDH is thought to be a key enzyme involved in tissue-specific regulation of steroid hormone metabolism (10, 39). Various forms of 20a-HSDH are found in the major steroid-producing tissues of mammals (adrenals, ovaries, testes, and placenta) and in liver, kidney, muscle, lymphatic organs, fibroblasts, and hematopoietic cells (4,28,29,45,47,49). Multiple forms of 20a-HSDH have been distinguished in several tissues, largely on the basis of steroid substrate specificity, pyridine nucleotide requirement, and intracellular location (2, 12, 37).…”
mentioning
confidence: 99%
“…The two ~OP-OIS, E and U, were previously reported as metabolites of cortisol in eviscerated rats and in cultured human fibroblasts (Sweat et a[., 1958). The 20a-01 epi-E was identified as a metabolite of cortisol in loose connective tissue of the rat ).…”
Section: Discussionmentioning
confidence: 89%