The metabolism of sodium cortisone 27-[35S]-sulphate in the rat

Gatehouse, P. W.; Roy, A.B.; Dodgson, K. S.; Powell, Gavin; Lloyd, Alun G.; Olavesen, Anthony H.

doi:10.1042/bj1270661

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…These studies with diethylstilboestrol monosulphate and diethylstilboestrol disulphate have shown that both compounds, in company with others previously studied (see, e.g., Gatehouse et al, 1972;Curtis et al, 1969;Hearse et al, 1969), represent sulphate esters that are not metabolically inert in vivo.…”

Section: Experiments With Diethylstilboestrolmono[35s]sulphatesupporting

confidence: 54%

Metabolic fates of diethylstilboestrol sulphates in the rat

Barford¹,

Olavesen²,

Curtis³

et al. 1977

Biochemical Journal

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The metabolic fates and modes of excretion of diethylstilboestrol mono [35S] Diethylstilboestrol has been used as a synthetic oestrogen in humans and in food-producing animals. It has been shown to have carcinogenic properties in a number of animal species (Umberger, 1975) and its use has been associated with the occurrence of tumours in humans (Herbst et al., 1972).The metabolic fate of diethylstilboestrol has been studied in several animal species (Abou-EI-Makarem et al., 1967) and it has been shown that biliary excretion as a glucuronic acid conjugate represents a major pathway for elimination (Klaasen, 1973). The disulphate ester of diethylstilboestrol, which is approximately half as active as diethylstilboestrol itself with respect to oestrogenic activity (Bishop et al., 1951), has been used as a water-soluble form of the synthetic oestrogen. Nevertheless, the metabolism of sulphated forms of diethylstilboestrol has not been reported.

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