1971
DOI: 10.1016/0005-2760(71)90176-7
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The metabolism of stigmasterol and cholesterol by Paramecium aurelia

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Cited by 22 publications
(12 citation statements)
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“…For Paramecium, an apparent link between growth support and fatty acyl esterification of sterols has been reported (Conner et al, 1971). This would clearly favour a hypothesis involving essential sterols in the transport, metabolism or transacylation of fatty acids.…”
Section: Discussionmentioning
confidence: 92%
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“…For Paramecium, an apparent link between growth support and fatty acyl esterification of sterols has been reported (Conner et al, 1971). This would clearly favour a hypothesis involving essential sterols in the transport, metabolism or transacylation of fatty acids.…”
Section: Discussionmentioning
confidence: 92%
“…1 depicts the influence of exogenous stigmasterol concentration on the growth of P. tetraurelia in monoxenic culture. In these experiments, stigmasterol and its metabolite, 7-dehydrostigmasterol (Conner et al, 1971 ;Whitaker & Nelson, 1987), served as both the bulk membrane sterol and the nutritionally required phytosterol. Under this condition, near maximal growth was realized at an exogenous stigmasterol concentration of 5.0 yg ml-l (Pitt, 1980).…”
Section: Culturesmentioning
confidence: 99%
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“…Apart from free sterols esterified ones have been reported from the protozoan Paramecium (Conner et al, 1971) up to mammalian brains (Eto & Suzuki, 1971). In molluscs, the composition of sterols and the potential capacity of synthesizing sterols in various representatives have been fairly well documented (review: Voogt, 1972a).…”
mentioning
confidence: 99%
“…Interestingly, however, Paramecium tetraurelia does not have C-24 dealkylation activity(Conner et al, 1971) and requires phytosterols(Whitaker and Nelson, 1987). Overall, sterol metabolism in T. thermophila seems to be the evolutionary product of a fascinating combination of gene losses (e.g., typical eukaryotic genes involved in sterol biosynthesis) combined with acquisition of bacterial genes to allow for synthesis of unusual compounds, with potentially novel mechanisms of sterol modification.…”
Section: Studies On Membrane Lipids In Tetrahymenamentioning
confidence: 99%