The Metabolism of Subcutaneous Adipose Tissue in the Immediate Postnatal Period of Human Newborns. 2. Developmental Changes in the Metabolism of 14C-(U)-D-Glucose and in Enzyme Activities of Phosphofructokinase (PFK; EC. 2.7.1.11) and β-Hydroxyacyl-CoA Dehydrogenase (HAD; EC. 1.1.1.35)

Novák, Milan; Monkus, E.; Wolf, H.G.; Stave, Uwe

doi:10.1203/00006450-197204000-00002

Cited by 16 publications

(12 citation statements)

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“…More free fatty acids may undergo direct oxidation in neonatal subcutaneous white adipose tissue than in the same tissue in adults [21]. The increase in /?-hydroxyacyl-CoA dehydrogenase activity associated with the mitochondrial fraction in subcutaneous adipose tissue during postnatal development suggests such a possibility [28]. There are still insufficient data to confirm or refute the quantitative significance of fatty acid oxidation in developing white adipose tissue in human neonates in comparison with brown fat in human neonates or lower mammals on the one hand, or to white adipose tissue in the human adult on the other hand, where the major function of this tissue is known to be the storage of lipid and the controlled delivery of free fatty acids and glycerol to other organs.…”

Section: Discussionmentioning

confidence: 93%

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The Metabolism of Subcutaneous Adipose Tissue in the Immediate Postnatal Period of Human Neonates. III. Role of Fetal Glycogen in Lipolysis and Fatty Acid Esterification in the First Hours of Life

1973

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ExtractTotal glycogen phosphorylase activity in neonatal adipose tissue is significantly increased immediately after birth (0-6 hr) and rapidly decreases to a relatively constant level. Fluoride-stimulated adenyl cyclase activity in homogenates of adipose tissue from neonates is directly correlated with the length of time from the onset of labor {y = 0.665 + 7.88*; P < 0.02). No significant differences are found between infants 1-10 hr of age and 2-A days of age. The ATP content decreases rapidly in the first hours of life and is inversely correlated with the length of time since the onset of labor (logjy = -0.657 -0.0164*; P < 0.01). The ATP content starts to increase approximately 24 hr after birth. Changes in ATP content are directly correlated with glycogen content and glycerol release from neonatal adipose tissue. SpeculationThe intensity of lipolysis in neonatal adipose tissue depends on various factors, one of the most important being an adequate energy supply. The increased glycogen content in adipose tissue immediately after birth and the rapid rate of utilization of glycogen-derived glucose appear to be major factors involved in the production of ATP required for glycogenolysis, lipolysis, and fatty acid activation during the early adaptation of the neonate to extrauterine life. Introductionof substrate stores into utilizable form. Before the neonate is capable of covering his energy requirements by The early adaptation of the fetus to extrauterine life ingestion of sufficient milk, he is dependent on his own depends mainly on conversion of the potential energy endogenous energy sources. This time may be charac-

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Section: Discussionmentioning

confidence: 93%

“…Glycogen breakdown certainly begins before delivery and may be initiated at the onset of labor. Previous investigations in vitro in subcutaneous adipose tissue with 14 C-(U)-n-glucose show increased glucose oxidation and incorporation of glucose carbons into triglyceride immediately after birth, in comparison with older neonates [28].…”

Section: Discussionmentioning

confidence: 99%

The Metabolism of Subcutaneous Adipose Tissue in the Immediate Postnatal Period of Human Neonates. III. Role of Fetal Glycogen in Lipolysis and Fatty Acid Esterification in the First Hours of Life

1973

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“…Subcutaneous white adipose tissue samples (20-60 mg) were obtained from the gluteal region of normal fullterm infants at 1 hr to 7 days of age and from adult volunteers using a percutaneous needle biopsy technique (21,25) for which written informed consent was obtained (36).…”

Section: Methodsmentioning

confidence: 99%

“…In contrast to newborn rodents, human newborn infants have a greater abundance of white than brown adipose tissue (9). Although the main function of white fat is probably to provide substrates (free fatty acids, glycerol) for other tissues of the body, its capacity to oxidize fatty acids increases postnatally (25).…”

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Carnitine and Development of Newborn Adipose Tissue

et al. 1978

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“…Our previous studies have indicated that substrates formed by glycolysis may ensure sufficient ATP production for only a short period following birth [19,21]. Later oxidation of fatty acids appears to be the main pathway supporting energy-requiring processes in cluding triglyceride breakdown [22], However, the accumulation of fatty acids produced by accelerated lipolysis may alter the mitochondrial capability to produce ATP.…”

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Oxidation of Fatty Acids by Mitochondria Obtained from Newborn Subcutaneous (White) Adipose Tissue

Novák

Penn-Walker

Monkus³

1974

Neonatology

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Oxidation of fatty acids was found to be both carnitine-dependent and carnitine-independent in mitochondria obtained from human newborn subcutaneous fat. A higher affinity of microsomes than that of mitochondria for free fatty acids was indirectly demonstrated by using microsomal fractions as substrate carriers. Oxygen consumption was detected in microsomal fractions and was associated with double bond formation. This may substantially contribute to the oxygen consumption of the developing adipocyte. The mechanisms involved in fatty acid oxidation in mitochondria of developing white adipocyte of the human newborn are similar to those described for mammalian brown fat.

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The Metabolism of Subcutaneous Adipose Tissue in the Immediate Postnatal Period of Human Newborns. 2. Developmental Changes in the Metabolism of 14C-(U)-D-Glucose and in Enzyme Activities of Phosphofructokinase (PFK; EC. 2.7.1.11) and β-Hydroxyacyl-CoA Dehydrogenase (HAD; EC. 1.1.1.35)

Cited by 16 publications

References 16 publications

The Metabolism of Subcutaneous Adipose Tissue in the Immediate Postnatal Period of Human Neonates. III. Role of Fetal Glycogen in Lipolysis and Fatty Acid Esterification in the First Hours of Life

The Metabolism of Subcutaneous Adipose Tissue in the Immediate Postnatal Period of Human Neonates. III. Role of Fetal Glycogen in Lipolysis and Fatty Acid Esterification in the First Hours of Life

Carnitine and Development of Newborn Adipose Tissue

Oxidation of Fatty Acids by Mitochondria Obtained from Newborn Subcutaneous (White) Adipose Tissue

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