The metabolite beta-aminoisobutyric acid and physical inactivity among hemodialysis patients

Molfino, Alessio; Amabile, Maria Ida; Ammann, Thomas; Farcomeni, Alessio; Lionetto, Luana; Simmaco, Maurizio; Lai, Silvia; Laviano, Alessandro; Fanelli, Filippo Rossi; Chiappini, Maria Grazia

doi:10.1016/j.nut.2016.07.012

Cited by 16 publications

(33 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported reduced serum BAIBA levels of 0.21-0.61 µM in patients with significantly reduced physical activity such as those on hemodialysis 13 . Animal research suggested that BAIBA levels were about 0.6-2 µM in mouse plasma 15 .…”

Section: Discussionmentioning

confidence: 90%

“…A previous study reported that BAIBA attenuates insulin resistance, suppresses inflammation, and induces fatty acid oxidation via the AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor δ (PPARδ) signaling pathway in skeletal muscle 12 . BAIBA levels increase in circulation in response to exercise, thus it serves as a contraction-induced myokine that increases energy expenditure and participates in exercise-induced protection from metabolic diseases like type 2 diabetes [13][14][15] . However, the distribution of L-and D-BAIBA is contradictory as most studies report total BAIBA 9 .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Wang

Bian

et al. 2020

Commun Biol

View full text Add to dashboard Cite

Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60-80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites associated with BMD and osteoporosis. In peripheral blood monocytes, dihydropyrimidine dehydrogenase, an enzyme essential to D-BAIBA generation, exhibited positive association with physical activity and hip BMD. Along with their signaling roles, BAIBA and GABA might serve as biomarkers for diagnosis and treatments of osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Wang

Bian

et al. 2020

Commun Biol

View full text Add to dashboard Cite

show abstract

“…Women and men ≥18 years chronically maintained on HD, participating on a study investigating the role of nutrition and quality of life, whose baseline characteristics were previously described (Molfino et al, 2017), underwent to a follow-up of 24 months. In summary, 52 patients are chronically treated at the HD center and the inclusion criteria consisted in enrolling the entire HD cohort with the exception of patients with highly catabolic diseases, such as cancer, chronic infections, and AIDS, and the absence of informed consent, as previously shown (Molfino et al, 2017). The sample size we used was representative of the entire number of patients, respecting the inclusion criteria, treated at the single Dialysis Unit.…”

Section: Methodsmentioning

confidence: 99%

“…Physical inactivity is associated with the risk of falls, hospitalizations, cognitive impairment, vascular access failure, and poor quality of life among HD patients (Johansen et al, 2013a; Sy and Johansen, 2017) and exercise may be effective to reduce this risk (Johansen et al, 2013b). We recently investigated the presence of physical inactivity and its barriers among a cohort of HD patients and the association with the myokine beta-aminoisobutyric acid (BAIBA) (Molfino et al, 2017), which is formed by the catabolism of valine, determining several beneficial effects on muscle metabolism in an autocrine/paracrine manner (Molfino et al, 2017; Huh, 2018). In particular, BAIBA secretion increases with exercise and induces browning of white fat and hepatic beta-oxidation having potential implication in the physiological mechanisms of physical activity (Roberts et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Physical Activity Change During Hemodialysis and Its Association With Body Composition and Plasma BAIBA Levels

et al. 2019

Self Cite

View full text Add to dashboard Cite

Rationale: Low physical activity is frequent in end stage renal disease. We evaluated the longitudinal change in physical activity and its barriers in hemodialysis (HD) patients and the association between the patterns of physical activity change, body composition, and beta-aminoisobutyric acid (BAIBA), as circulating myokine. Methods: This is an observational study, where HD patients were considered in a 24-month follow-up. We assessed overtime the change of physical inactivity and its barriers by validated questionnaires, body composition by bioimpedance analysis, muscle strength by hand-dynamometer, and plasma BAIBA levels by liquid chromatography spectrometry. Parametric and non-parametric analyses were performed, as appropriate. Results: Out of the 49 patients studied at baseline, 39 completed the first-year follow-up, and 29 completed the second year. At month 12, active patients had higher intracellular water (ICW) ( P = 0.001) and cellular mass ( P < 0.001), as well as at month 24 ( P = 0.012, P = 0.002; respectively) with respect to inactive. A significant reduction in ICW was shown at month 12 ( P = 0.011) and month 24 ( P = 0.014) in all patients. The barrier “reduced walking ability” was more frequent in inactive patients with respect to active at month 12 ( P = 0.003) and at month 24 ( P = 0.05). At month 24, plasma BAIBA levels were higher among active patients with respect to inactive ( P = 0.043) and a correlation was seen between muscle strength and ICW ( r = 0.51, P = 0.005); normalizing BAIBA per body mass index, we found it lower with respect to baseline ( P = 0.004), as well as after correcting per ICW ( P = 0.001), as marker of muscle mass. Conclusion: A high prevalence of physical inactivity persisted during a 24-month follow-up in this cohort. We found an association between physical activity and a decline in marker of muscularity and reduced plasma BAIBA levels.

show abstract

“…These factors are also common pathophysiological features of fluid control in hemodialysis patients due to chronic renal failure. Body composition and fluid status monitoring assessed by non-invasive BIA, especially intracellular water (ICW), have been shown to be of prognostic value in acute decompensated heart failure, [11] acute kidney injury under continuous hemodiafiltration, [12] and patients with chronic renal failure under hemodialysis [13,14]. Therefore, BIA has also been shown to be an applicable tool for assessment of ICW, even in patients with possible overhydration or vigorous fluid status changes.…”

Section: Introductionmentioning

confidence: 99%

Clinical implications with tolvaptan on monitored bioimpedance-defined fluid status in patients with cirrhotic ascites: an observational study

et al. 2020

View full text Add to dashboard Cite

Background: Prognostic value or clinical implications of fluid status monitoring in liver cirrhosis are not fully elucidated. Tolvaptan, an orally available, selective vasopressin V2-receptor antagonist approved for hyponatremia in the United States and European Union. It is also used for cirrhotic ascites at a relatively low dose (3.75 mg to 7.5 mg) in Japan, exerts its diuretic function by excreting electrolyte-free water. We hypothesized that bioimpedancedefined dynamic changes in fluid status allow prediction of response of V2 antagonism and survival in cirrhotic patients. Methods: In this prospective observational study, 30 patients with decompensated liver cirrhosis who were unresponsive to conventional diuretics were enrolled. Detailed serial changes of body composition that were assessed by using non-invasive bioimpedance analysis (BIA) devices, along with biochemical studies, were monitored at 5 time points. Results: Sixteen patients were classified as short-term responders (53%). Rapid and early decrease of BIA-defined intracellular water, as soon as 6 h after the first dose (ΔICW BIA %-6 h), significantly discriminated responders from non-responders (AUC = 0.97, P < 0.0001). ΔICW BIA %-6 h was highly correlated with the change of BIA-derived phase angle of trunk, e.g. reduced body reactance operated at 50 kHz after 24 h of the first dose of tolvaptan. Lower baseline blood urea nitrogen and lower serum aldosterone were predictive of a rapid and early decrease of ICW BIA. A rapid and early decrease of ICW BIA in response to tolvaptan was also predictive of a better transplant-free survival. Conclusions: BIA-defined water compartment monitoring may help predict short-term efficacy and survival in decompensated cirrhotic patients treated with tolvaptan.

show abstract

The metabolite beta-aminoisobutyric acid and physical inactivity among hemodialysis patients

Abstract: Physical inactivity is highly prevalent among patients on HD and BAIBA correlates with barriers to physical activity reported by inactive patients.

Cited by 16 publications

References 26 publications

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis

Longitudinal Physical Activity Change During Hemodialysis and Its Association With Body Composition and Plasma BAIBA Levels

Clinical implications with tolvaptan on monitored bioimpedance-defined fluid status in patients with cirrhotic ascites: an observational study

Contact Info

Product

Resources

About