The metabolomics responses of Chinese mitten-hand crab (Eriocheir sinensis) to different dietary oils

Ma, Qianqian; Chen, Qing; Shen, Zhenhua; Li, Dongliang; Han, Tao; Qin, Jianguang; Chen, Liqiao; Du, Zhen‐Yu

doi:10.1016/j.aquaculture.2017.05.032

Cited by 67 publications

(38 citation statements)

References 84 publications

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“…Dietary lipid is essential to farmed fish and crustaceans (Chen et al, ; Hung, Cho, & Slinger, ; Saoud, Yta, & Ghanawi, ; Suprayudi, Takeuchi, & Hamasaki, ; Wu et al, ). Dietary lipid sources and levels exert great effects on growth performance (Yang et al, , ), survival, feed utilization, antioxidant defense, immunity and disease resistance in different aquatic animals (Ma et al, ; Sheen & Wu, ; Wang, Chen, et al, ). Fish meal and fish oil are the best lipid sources for aquacultural feed.…”

Section: Introductionmentioning

confidence: 99%

A combination of vitamins C and E alleviates oxidized fish oil‐induced hepatopancreatic injury in juvenile Chinese mitten crabEriocheir sinensis

et al. 2019

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Dietary lipid oxidation is a lasting concern to aquafeed manufacturers and aquaculture farmers. Here, we determined if there was an association between oxidized fish oil (OFO) and hepatopancreatic injury in Chinese mitten crab, and evaluated the alleviating effects of a combination of vitamins C and E on hepatopancreatic injury. There were significant reductions in the body weight gain, hepatopancreatic index, and feed efficiency in crabs that received OFO. Diets with OFO also resulted in reduced crude fat contents in the hepatopancreas and muscle tissues, and alternations in the hepatopancreatic fatty acid compositions, especially a reduction in polyunsaturated fatty acids. Moreover, dietary OFO exposure reduced the antioxidant defense and non‐specific immune response, caused hepatopancreatic injury, and even apparent whitening. An ultrastructural examination of the whitened hepatopancreas revealed that hepatopancreatic cells were injured at varying degrees following OFO exposure. The combination of vitamins C and E could efficiently maintain a constant fatty acid profile in the hepatopancreas exposed to OFO, thus alleviating OFO‐induced hepatopancreatic injury. In addition, a biochemical analysis indicated that a combination of vitamins C and E not only improved the antioxidant status by mitigating the harmful effects of oxidized oil, but also modulated non‐specific immune responses in the crab that received OFO. Overall, OFO‐induced hepatopancreatic injury may be alleviated by a dietary combination of vitamins C and E, and the feeding of rancid forage fish or diets that contain highly oxidized oil is likely a cause of hepatopancreatic necrosis that is frequently observed in farmed crabs.

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Section: Introductionmentioning

confidence: 99%

A combination of vitamins C and E alleviates oxidized fish oil‐induced hepatopancreatic injury in juvenile Chinese mitten crabEriocheir sinensis

et al. 2019

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“…In most of these studies, LA was regarded as the essential fatty acid in tilapia and the oils enriched with LA, such as soybean oil, safflower oil, have also been reported to be good for tilapia growth (Ferreira et al, ; Li, Lim, Klesius, & Welker, ; Lim et al, ). Nevertheless, several studies have also indicated that olive oil enriched with OA could be well utilized as a good substrate for energy supply to improve growth in some aquatic animals (Ma et al, ; Seno‐O et al, ). Moreover, EPA and DHA in fish oil have been demonstrated to be highly deposited in fish tissues improving the fish nutritional value (Alsouti et al, ; Ng et al, ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of effects of dietary‐specific fatty acids on growth and lipid metabolism in Nile tilapia

et al. 2019

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The dominant fatty acids (FAs) in oils are often used to explain different nutritional effects of dietary oils in fish. However, the amounts of dominant FAs among oils are different, and the nutritional roles of these important FAs in fish have not been precisely compared at similar levels in feeding trials. In the present study, different amounts of palmitic acid were added to safflower oil (SO), olive oil (OO) and fish oil (FO) to obtain comparable amounts (about 550 g/kg of total FAs) of 18:2n‐6, 18:1n‐9 and 20:5n‐3 + 22:6n‐3 and subsequently fed to Nile tilapia (11.1 ± 0.01 g) for 8 weeks. The results showed similar growth among groups but FO group obtained lower fat deposition, serum ALT and AST activities, compared to OO. Lipogenesis‐related gene expressions were higher in OO group than FO group in liver, muscle and adipose tissue, but there were only few differences in these genes between SO and FO groups. Lipid catabolism genes in FO group were higher than OO and SO groups in adipose tissue, but not in muscle, and the significantly higher expressions of CPT1b and PPARα were only observed in liver. Overall, dietary 18:2n‐6, 20:5n‐3 and 22:6n‐3 were beneficial to normal growth and lipid metabolism, whereas high amount of 18:1n‐9 induced lipid deposition and liver damage in Nile tilapia.

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“…The distinct reprogrammed metabolism was mainly involved valine, leucine and isoleucine biosynthesis, propanoate metabolism, TCA cycle, alanine, aspartate and glutamate metabolism, taurine and hypotaurine metabolism, glycerolipid metabolism, glyoxylate and dicarboxylate metabolism, as well as pyruvate metabolism. Just as Ma et al [29] said in the report, the metabolic pathways identi ed through the signi cantly different metabolites represent the typical characteristics response of living systems to pathophysiological stimuli or genetic modi cation [30]. Comprehensive consideration of our research results, metabolites changed at different stages, such as pyruvic acid, alanine, proline, betaglycerophosphoric acid, 3-hydroxypropionic acid, canavanine and lactic acid, were selected as potential biomarkers for the early diagnosis of fatty liver disease.…”

Section: Discussionmentioning

confidence: 87%

“…In order to systematically demonstrate the metabolic response to overfeeding, the signi cantly different metabolites combined with corresponding metabolic pathways are shown Table 1. The metabolite with the largest difference between the D0 group and the D7 group was glutathione (8.101 fold higher in the D7 group than that in the D0 group), which is an amino acid and a tripeptide, as well as a well-known antioxidative factor [29]. This nding is in line with a previous study in human, in which γ-glutamyl dipeptide could serve as biomarkers for discrimination among different forms of liver disease, and had a positive correlation with glutathione, providing speci c information for different liver diseases [4].…”

Section: Discussionmentioning

confidence: 99%

A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via Gc-tof/ms

Gong

Lyu

Shi

et al. 2020

Preprint

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Background:During the process of fatty liver production by overfeeding, the levels of endogenous metabolites in the serumof geese would change dramatically. This study investigated the effects of overfeeding on serum metabolism of Landes geese and the underlying mechanisms using a metabolomics approach.Results:Sixty Landes geese of the same age were randomly divided into the following 3 groups: D0 group (free from gavage); D7 group (overfeeding for 7 days); D25 group (overfeeding for 25 days). The results showed that overfeeding significantly increased the body weight and the liver weight of geese. Serum enzymatic activities and serum lipid levels were significantly enhanced following overfeeding.Gas chromatography time-of-flight/massspectrometry (GC-TOF/MS) was employed to explore the serum metabolic patterns, and to identify potential contributors to the formation of fatty liver and the correlatedmetabolic pathways. A large number of endogenous molecules in serum were altered, especially at the late stage of overfeeding (7 days to 25 days). Continuous elevated levels of pyruvic acid, alanine, proline and beta-glycerophosphoric acid and reduced lactic acid level were observed in the serum of overfed geese. Pathway exploration found that the most of significantly different metabolites were involved in various amino acids metabolism, carbohydrate metabolismand lipid metabolism.Conclusions: These findings pinpoint specific metabolite changes and identify potential biomarkers for early diagnosis of fatty liver disease, as well as provide insights into the perturbation of metabolic pathways involved in fatty liver formation.

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The metabolomics responses of Chinese mitten-hand crab (Eriocheir sinensis) to different dietary oils

Cited by 67 publications

References 84 publications

A combination of vitamins C and E alleviates oxidized fish oil‐induced hepatopancreatic injury in juvenile Chinese mitten crabEriocheir sinensis

A combination of vitamins C and E alleviates oxidized fish oil‐induced hepatopancreatic injury in juvenile Chinese mitten crabEriocheir sinensis

Comparison of effects of dietary‐specific fatty acids on growth and lipid metabolism in Nile tilapia

A Serum Metabolic Profiling Analysis During the Formation of Fatty Liver in Landes Geese via Gc-tof/ms

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