The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders

Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats

“…In recent years, the metabotropic glutamate receptor 5 (mGlu5) has gained attention as a potential biomarker and molecular mediator of PTSD susceptibility. 8,9 This Gq/11 protein-coupled receptor mediates forms of synaptic plasticity underpinning hippocampal-dependent memory, and particularly, affective learning processes. [9][10][11] Further, there is mounting evidence from human postmortem investigations and clinical neuroimaging studies that suggest dysregulation of the mGlu5 receptor in PTSD.…”

“…8,9 This Gq/11 protein-coupled receptor mediates forms of synaptic plasticity underpinning hippocampal-dependent memory, and particularly, affective learning processes. [9][10][11] Further, there is mounting evidence from human postmortem investigations and clinical neuroimaging studies that suggest dysregulation of the mGlu5 receptor in PTSD. Specifically, using positron emission tomography (PET) to measure mGlu5 receptor availability in vivo, our group has previously demonstrated higher mGlu5 receptor availability in PTSD that significantly correlates with symptom severity.…”