The Metal—Halogen Exchange Reaction Between ortho‐Substituted Aryl Halides and Ph₂CuLi×LiCN: Scope and Applicability for Coupling Reactions.

Abstract

Reactions of organo-metal compounds Reactions of organo-metal compounds O 0350The Metal-Halogen Exchange Reaction Between ortho-Substituted Aryl Halides and Ph 2 CuLi·LiCN: Scope and Applicability for Coupling Reactions. -(CETIN, F.; SENOGUL, H. B.; GEZER, S.; ASTLEY, D.; ASTLEY*, S. T.; J. Organomet. Chem. 689 (2004) 1, 154-157; Dep. Chem., Univ. Ege, TR-35100 Bornova, Turk.; Eng.) -S. Adam 21-043

The Meyers Reaction (1994-2010)

“…The coupling products 21 were obtained in fair to reasonable yields (40-78%), although the reactions with Grignard reagents required a larger amount of reagent and/or longer reaction times. Compound 20 and the related fluoro and bromo derivatives undergo manganese-catalyzed substitution of the halogen upon reaction with Grignard reagents [17,18]. The dialdehyde 24 can be prepared by a "double" Meyers substitution (Scheme 6) [19].…”