1984
DOI: 10.1002/9780470123027.ch5
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The Metallobiochemistry of Zinc Enzymes

Abstract: The honour and opportunity of being invited to address you on the occasion of Professor Houtman's retirement is very much appreciated. However, having met him yesterday, I am convinced that I am not here to help celebrate his retirement as much as to initiate his new career.Just like careers, the role of metals in biology can be viewed from multiple points of view. In the past, metals have variously been thought to be beneficial, toxic or to serve no purpose at all in biology. It is not very long ago that docu… Show more

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Cited by 175 publications
(90 citation statements)
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“…The majority of enzymes in the latter category bind zinc only loosely, and are activated by the addition of a variety of metal ions (Vallee and Wacker 1970). According to Vallee and Galdes (1984), zinc enzymes are involved in the replication, transcription, and translation of genetic material of all species. The specific role of zinc in gene transcription has been characterized by Wu and Wu (1987).…”
Section: Miscellaneous Biochemical Effectsmentioning
confidence: 99%
“…The majority of enzymes in the latter category bind zinc only loosely, and are activated by the addition of a variety of metal ions (Vallee and Wacker 1970). According to Vallee and Galdes (1984), zinc enzymes are involved in the replication, transcription, and translation of genetic material of all species. The specific role of zinc in gene transcription has been characterized by Wu and Wu (1987).…”
Section: Miscellaneous Biochemical Effectsmentioning
confidence: 99%
“…[3] The study of this and other zinc enzymes such as carboxypeptidases A and B, alcohol dehydrogenases, alkaline phosphatases, and thermolysin, formed the basis of zinc metalloenzymology. [11] The functions of zinc in enzymes were then designated as catalytic, coactive (or cocatalytic) and structural. [3] These realizations were pivotal.…”
Section: Introductionmentioning
confidence: 99%
“…Zinc is an essential trace element and plays important roles as a component of many co-factors and enzymes involved in protein synthesis (Vallee and Goldes, 1984). Clearly, there exists in all cells an optimal zinc requirement for growth and function.…”
Section: Discussionmentioning
confidence: 99%