The metastasis-associated 67-kDa laminin receptor is involved in G-CSF–induced hematopoietic stem cell mobilization

Selleri, Carmine; Ragno, Pia; Ricci, Patrizia; Visconte, Valeria; N, Scarpato; Carriero, Maria Vincenza; Rotoli, Bruno; Rossi, Guido; Montuori, Nunzia

doi:10.1182/blood-2005-11-012625

Cited by 31 publications

(29 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 Recently, a p67 nonintegrin laminin receptor was reported to be functionally active in homing and G-CSF-induced mobilization of human HPCs. 45,65 In addition, several other laminin receptors including integrin ␣2␤1, ␣-dystroglycan, Lutheran glycoprotein, and heparan sulfate proteoglycans, 20,[44][45][46]66,67 have been reported in adult hematopoietic cells. The possible expression and role of these receptors during fetal HSPC mobilization and homing should be addressed in further studies.…”

Section: Discussionmentioning

confidence: 99%

Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells

Qian

Georges-Labouesse

Nyström

et al. 2007

Blood

View full text Add to dashboard Cite

Homing of hematopoietic stem cells (HSCs) into the bone marrow (BM) is a prerequisite for establishment of hematopoiesis during development and following transplantation. However, the molecular interactions that control homing of HSCs, in particular, of fetal HSCs, are not well understood. Herein, we studied the role of the ␣6 and ␣4 integrin receptors for homing and engraftment of fetal liver (FL) HSCs and hematopoietic progenitor cells (HPCs) to adult BM by using integrin IntroductionDuring transplantation, intravenously injected hematopoietic stem and progenitor cells (HSPCs) selectively transmigrate through the sinusoidal walls into the bone marrow (BM) niches to engraft and reconstitute hematopoiesis. This process, called homing, is a rapid multistep process involving multiple adhesion receptor and ligand pairs, leading first to reversible adhesion of circulating HSPCs to endothelial cells of BM sinusoids and subsequently transmigration through the sinusoidal walls into the specific hematopoietic niches. 1 The adhesive interactions mediated by distinct receptors on hematopoietic cells regulate the localization, migration, and other HSPC functions within their native microenvironments, and are likely to define their homing potential in a transplantation setting. 2 The rate of reconstitution following transplantation varies depending on the source of hematopoietic stem cells (HSCs), suggesting developmentally regulated and cell type-specific differences in expression and function of homing receptors. Cord blood grafts are associated with a particularly delayed hematopoietic reconstitution. 3 In contrast, experimental studies have shown a more rapid and robust reconstitution of both human and mouse fetal liver (FL) HSCs than adult BM HSCs. 4,5 Increasing HSC homing and engraftment efficiency might offer a means to enhance reconstitution, which may be critically important if donor cell numbers are limiting, as frequently observed in cord blood units. 3 Therefore, knowledge of the specific molecular mechanisms involved in homing and engraftment of different types of HSPCs is of clinical significance for the development of clinical transplantation methods.Mouse models for mammalian hematopoiesis are widely used to study developmentally regulated HSC functions, including mobilization, homing, and engraftment. 6 During mammalian ontogeny, HSCs develop sequentially in distinct hematopoietic tissues, beginning in the yolk sac and subsequently in the aorta-gonadmesonephros region in the embryo proper. At embryonic day 10 (E10) in mice, definitive hematopoiesis arises in the liver, which is the main site of hematopoiesis throughout subsequent fetal development. 7 In later gestation, hematopoiesis expands into spleen (E15) and thereafter into BM (E17). This shift in hematopoiesis is accomplished by migration of liver HSPCs into spleen and BM, and consequently, is associated with mobilization of large numbers of HSPCs into the bloodstream. 6 Despite the central role of migration and homing in stem-cell biology and in st...

show abstract

Section: Discussionmentioning

confidence: 99%

Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells

Qian

Georges-Labouesse

Nyström

et al. 2007

Blood

View full text Add to dashboard Cite

show abstract

“…After all, a careful analysis (see f.i. [14], [15,16,17,18]) seems to unveil that no actual experiment, among the ones mentioned by the authors quoted before, is a genuine "one-way" experiment. As a consequence, it seems reasonable to suspect that the parameters appearing in the test-theories mentioned before could actually be beyond the reach of experimental knowledge: in other words, these parameters could be "conventional" in the sense that their numerical values have no effect on the output of any actual experiment.…”

Section: Introductionmentioning

confidence: 94%

“…In recent years, Franco Selleri [15,16,17,18] has sided against both the conventionalist approach and the SRT, maintaining the cause of realism in a Lorentz-like background; yet he agrees with one of the main points of the conventionalist attitude, namely the statement that, in any IRF, "the costancy of the one-way speed of light is a mere convention without any empirical cornerstone" 7 . Unlike the AVS approach, Selleri approach is not formal but truly physical, or to be exact conceptual, and even philosophical; it is not surprising that such an approach gave rise to a wide and fascinating discussion about the foundations of SRT [15,16,17,18], [5], [22], [11], [23].…”

Section: Between Conventionalism and Realism: Selleri's Approachmentioning

confidence: 99%

Synchronization Gauges and the Principles of Special Relativity

2004

View full text Add to dashboard Cite

The axiomatic bases of Special Relativity Theory (SRT) are thoroughly re-examined from an operational point of view, with particular emphasis on the status of Einstein synchronization in the light of the possibility of arbitrary synchronization procedures in inertial reference frames. Once correctly and explicitly phrased, the principles of SRT allow for a wide range of 'theories' that differ from the standard SRT only for the difference in the chosen synchronization procedures, but are wholly equivalent to SRT in predicting empirical facts. This results in the introduction, in the full background of SRT, of a suitable synchronization gauge. A complete hierarchy of synchronization gauges is introduced and elucidated, ranging from the useful Selleri synchronization gauge (which should lead, according to Selleri, to a multiplicity of theories alternative to SRT) to the more general Mansouri-Sexl synchronization gauge and, finally, to the even more general Anderson-Vetharaniam-Stedman's synchronization gauge. It is showed that all these gauges do not challenge the SRT, as claimed by Selleri, but simply lead to a number of formalisms which leave the geometrical structure of Minkowski spacetime unchanged. Several aspects of fundamental and applied interest related to the conventional aspect of the synchronization choice are discussed, encompassing the issue of the one-way velocity of light on inertial and rotating reference frames, the GPS's working, and the recasting of Maxwell equations in generic synchronizations. Finally, it is showed how the gauge freedom introduced in SRT can be exploited in order to give a clear explanation of the Sagnac effect for counter-propagating matter beams. 1

show abstract

“…In response to mobilizing agents such as G-CSF and signaling through the laminin receptor, increased numbers of HSCs circulate out of the bone marrow [86]. The laminin receptor has 7 npg also been shown to play a key role in cancer metastasis [87]. Similarly, stromal cell derived factor and its receptor CXCR4 form a critical regulatory axis for HSC migration, engraftment and homing [88][89][90][91][92], and also function in the metastasis of breast, prostate and other types of cancer [73,[93][94][95][96][97][98][99][100].…”

Section: Stem Cell Niche and Tumor Migrationmentioning

confidence: 99%