The object of research is the analysis of the state of development of methods of optimal planning of multifactorial experiment on cost and time indicators. The subject of the research is the methods of optimization of multifactor experiment plans in terms of cost and time indicators. The objective: the development of practical recommendations for the application of existing optimization methods of multifactorial experiment plans in terms of cost and time criteria based on their comparative analysis. The tasks are the comparing of optimization methods of multifactorial experiment plans by characteristics: the allowable number of factors for effective optimization, type of plan, accuracy of the method, the number of optimization criteria, speed; development of practical recommendations for the use of these methods; the determine of directions for further development of the research topic. Methods: method of comparative analysis, optimization methods based on the study of nature, combinatorial optimization methods, graph optimization methods, approximate optimization methods. The results of study. The 20 methods of multifactorial experiment plans in terms of cost and time criteria are analyzed. The 6 practical recommendations for their application in the range of factors number 2 < k ≤ 16 are given. Conclusions. The scientific novelty of the obtained results is the improved comparative analysis of existing methods of multifactorial experiment plans based on 5 characteristics in terms of the experimenter's choice, namely: the allowable number of factors for effective optimization, type of plan, method accuracy, number of optimization criteria; speed-code. In the future, it is planned to study the classification of methods of multifactorial experiment plans, the development and improvement of two-criteria optimization methods for cost and time characteristics, the speed analysis of approximate optimization methods for k > 7 and their improvement.