The influence of this second Trumpler paper on subsequent astronomical development has been even greater than his 1925 evolution paper. The work sets out the first convincing demonstration of the presence of general interstellar extinction with a method that is direct and compelling. The argument was so convincing that it is generally credited with changing the prevailing opinion about the existence of general absorption, in contrast to the dark patches seen by Herschel, and photographed by Wolf, by Barnard (1913Barnard ( , 1919Barnard ( , 1927, and others. The patches are due to discrete clouds. The general absorption is due to a more diffusely spread medium.The paper is a lesson in exposition. One subject naturally flows into another. In 13 Journal pages, ten subjects are discussed, each of which has developed into separate central disciplines concerning interstellar dust.After an introductory paragraph which arrives directly at the point, Trumpler reviews the three types of absorption. Here he anticipates many of the methods that have subsequently been used for modern measurements. He describes general absorption and contrasts it with the "monochromatic" absorption of the stationary interstellar spectral lines first found by Hartman (1904) in the spectra of spectroscopic binaries. He then discusses the previous evidence for general absorption. The physical process of dispersion of the velocity of light (finally shown by Kienle in 1923 not to exist in connection with interstellar extinction) is dismissed as not being effective in the space between the stars.General star counts by Halm and by Schalen (references by Trumpler) are shown to be quite suggestive that extinction, increasing with distance, exists. However, this evidence is not decisive because interpretation of the star-count data rests on assumptions (generally unproved at the time) as to the true spatial distribution of the stars. Depending on the assumptions, the analysis yields a variety of answers.Trumpler then introduces his cluster method. Here *One in a series of invited reviews celebrating the eentenary of the Astronomical Society of the Pacific.