In order to study the influence of impeller structural parameters on the hydraulic performance and casting moulding of spiral centrifugal pumps, this paper selects a double vane spiral centrifugal pump with a specific rotation number of 170 as the research object. The Plackett–Burman experimental design is used to screen the influencing factors, and the results show that the vane thickness and the impeller outlet width are the significant influencing factors. Based on this result, five different scenarios were set for these two key parameters, numerical calculations were carried out using numerical simulation software for each of the five flow ratio cases, and casting simulations were carried out for the model of each scenario using AnyCasting6.0 to analyze the influence of these two factors on the hydraulic performance and casting forming of the spiral centrifugal pump. It was found that in terms of vane thickness, a moderate increase in vane thickness improved the hydraulic performance at small flow rates, but an excessive increase at large flow rates led to a decrease in efficiency and an increase in the probability of casting defects. In terms of impeller outlet width, increasing the outlet width caused the design point to be shifted, leading to a decrease in efficiency at small flow rates, but an increase in efficiency when the design flow rate was higher. At the same time, increasing the outlet width makes casting defects more likely to occur at the blade and back cover joint than on the blade surface. The study in this paper clarifies the significant effects of these two parameters on the performance and casting quality of spiral centrifugal pumps, and provides guidance for the optimal design of spiral centrifugal pumps.