The method of correction of hemorrhagic shock action on the pro- and antioxidant system of the periulceral stomach tissues in an experiment

Abstract

Annotation. The article presents the results of an experimental study about modeling hemorrhagic shock in animals with chronic gastric ulcer and further evaluation of the pro- and antioxidant system in periulceral tissues. The effect of local injection of platelets-rich plasma was also explored. Experiments were performed on 77 white laboratory rats. The level of NADPH-oxidase and superoxide dismutase, as indicators of pro- and antioxidant systems, after local periulceral injection of saline or platelet-rich plasma was explored in comparison with such levels in animals with ulcers and hemorrhagic shock without treatment. The obtained data were processed using the statistical software package SPSS 20.0 for Windows. The obtained data show a modulation of the pro- and antioxidant defense system towards destructive changes, characterized by the activation of pro-oxidant and inhibition of antioxidant enzymes in the mucous membrane of the periulceral zone in shock condition. Local periulceral injecting of platelet-rich plasma allows to reduce oxidative stress, activate the system of antioxidant enzymes and potentially accelerate repair processes in the periulceral zone.