The methods for the characteristic of adipose tissue in the organism and their clinical significance

Okorokov, P. L.; Васюкова, О. В.; Воронцов, А. В.

doi:10.14341/probl201460353-58

Cited by 11 publications

(3 citation statements)

References 25 publications

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“…В отличие от КТ и МРТ биоимпедансный метод является простым и доступным для практического здравоохранения способом оценки ВЖТ [4]. Преимуществами биоимпедансного метода являются его невысокая стоимость, надежность, отсутствие лучевой нагрузки и возможность проведения исследований в динамике [5].…”

Section: Assessment Of Abdominal Obesity Using Bioimpedance Analysisunclassified

Heterogeneity of abdominal obesity in patients with cardiovascular diseases

Miklishanskaya

Solomasova

Orlovsky

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim: To assess the content of visceral adipose tissue (VAT) in patients with abdominal obesity and its relationship with metabolic disorders.Material and methods. Patients with abdominal obesity (n=107) were included in the study. All participants had an assessment of anthropometric parameters (height, weight), calculation of body mass index (BMI), proportion of total adipose tissue and VAT (bioimpedance analyzer), high-density lipoprotein cholesterol (HDL-c) levels, triglycerides, fasting blood glucose, epicardial thickness adipose tissue (two-dimensional echocardiography).Results. The median share of VAT (bioimpedance method) was 13%. Patients with abdominal obesity are divided by VAT into 2 groups: ≥14% or ≤13%. Patients with VAT≥14% had significantly higher levels of triglycerides (1.76 [1.27; 2.38] mmol / L) and glucose (6.33 [5.78; 7.87] mmol / L), and below HDL-c levels (0.95 [0.85; 1.21] mmol / L) compared with patients with VAT≤13% (1.32 [1.02; 1.50], 5.59 [5, 11; 6.16] and 1.31 [1.07; 1.58] mmol / L, respectively; p<0.001 for all three comparisons). A significant correlation was found between VAT and triglyceride, glucose and HDL-c levels (r=0.40; r=0.40; r=-0.31, respectively; p<0.001).Conclusion. Persons with abdominal obesity are heterogeneous in the proportion of VAT. The proportion of VAT above the median is associated with metabolic disorders that are significant for the development and progression of atherosclerosis. An increase in BMI in obese individuals is not associated with an increase in VAT and an increase in the severity of metabolic disorders.

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Section: Assessment Of Abdominal Obesity Using Bioimpedance Analysisunclassified

Heterogeneity of abdominal obesity in patients with cardiovascular diseases

Miklishanskaya

Solomasova

Orlovsky

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…Жировая ткань -сложный эндокринный и метаболически высокоактивный орган, выделяющий многочисленные биоактивные молекулы с аутокринным, паракринным или системным действием, которому свойственны как защитные (хранение свободных триглицеридов при их избытке и высвобождение при необходимости), так и повреждающие эффекты: воспаление, фиброз, тромбообразование и атерогенез [1][2][3][4]. В настоящее время под ожирением понимают гетерогенное состояние, характеризующееся избыточным образованием интраабдоминальной жировой ткани с подкожным и висцеральным характером её распределения, последний является одним из ведущих факторов, увеличивающих вероятность развития сердечно-сосудистых заболеваний и ассоциированные с ними риски возникновения сахарного диабета 2 типа (СД2), инсулинорезистентности и нарушений липидного обмена [5][6][7].…”

Section: Introductionunclassified

Clinical and Morphological Features of Lipomatous Hypertrophy of Interatrial Septum in Patients with Diseases of Cardiovascular System

Solov’yeva¹,

Черданцева²,

Cheskidov³

et al. 2022

HMJ

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INTRODUCTION: Epicardial adipose tissue is usually located on the free wall of the right ventricle, the left ventricular apex, and the atria, but the valvular apparatus of the heart, the interventricular and interatrial septum can be subjected to lipotoxic damage. The accumulation of adipose tissue on the interatrial septum is of particular scientific interest and is described in the literature as lipomatous hypertrophy. AIM: To study the clinical and morphological features of lipomatous hypertrophy of interatrial septum in patients with diseases of the cardiovascular system. MATERIALS AND METHODS: Morphological examination of the hearts of 60 patients (30 men, 30 women), average age 74.6 ± 9.5 years was conducted. Morphometric parameters of the heart muscle and the aorta were evaluated. The studied heart material was stained with hematoxylin-eosin and according to Mallory and was processed by standard histological methods. RESULTS: The causes of death of patients were myocardial infarction, cerebral infarction, postinfarction cardiosclerosis and type 2 diabetes. The analysis of thickness of the interatrial septum in patients of different groups revealed lipomatosis of the interatrial septum in 83% of patients with postinfarction cardiosclerosis, in 80% of patients with myocardial infarction, in 70% with type 2 diabetes, in 66.7% with cerebral infarction. The thickness of the interatrial septum with lipomatous hypertrophy was 1.2 ± 0.12 cm in patients with myocardial infarction, 1.2 ± 0.11 cm in cerebral infarction, 1.2 ± 0.2 cm in postinfarction cardiosclerosis, 1.2 ± 0.15 cm in type 2 diabetes. There were no reliable differences in the thickness of the interatrial septum between the study groups. The correlation was established between the thickness of the interatrial septum with lipomatous alterations and hypertrophy of the anterior wall of the left ventricle (r = 0.7; р < 0.0001), fibrosis of the anterior wall of the left ventricle (r = 0.6; p = 0.03), thickness of epicardial fat (r = 0.5; p = 0.0002), as well as the interrelation with the thickness of the interventricular septum (r = 0.7; p < 0.05). The existence of epicardial fat in individuals with lipomatosis of the interatrial septum positively correlated with the thickness of the interventricular septum (r = 0.5; p = 0.01) and the thickness of the posterior wall of the left ventricle (r = 0.6; p = 0.001). The correlation relationship was also established between the thickness of the interatrial septum with lipomatous alterations and laboratory markers of cardiovascular risk: the level of total cholesterol (r = 0.8; p = 0.01), triglycerides (r = 0.6; p = 0.001), low-density lipoproteins (r = 0.7; p = 0.001). CONCLUSION: Taking into account the interrelations of lipomatous hypertrophy of the interatrial septum identified in the morphological and histological examination, as well as echocardiography data and some biochemical markers, this parameter can be recommended for use in assessment of cardiovascular risk in echocardiography.

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“…Данная методика позволяет оценить ряд показателей, которые отражают состояние основного обмена, активной клеточной массы, жировую и безжировую массу и общее содержание воды в организме [5]. Оценка композиционного состава тела позволяет получить более полную информацию о структурной составляющей тела ребенка и необходима как для осуществления контроля за физическим и психоэмоциональным здоровьем ребенка, так и для профилактики прогрессирования избыточной массой тела и ожирения [3,7,8].…”

Section: Introductionunclassified

Compositional Composition of the Body in Obese Children and Adolescents

Герасимчик

Girsh

2019

Transl. med. (Print)

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Background. The steady growth of obesity in the children’s age group determines the need for integrated modern approaches to diagnosis and therapy.Objective. To determine the body composition of adolescents with different body mass for the quantitative analysis of the internal environment of the organism using the method bioimpendancemetria.Design and methods. To determine the composition of the body, 121 adolescents aged 10–17 years were examined, the average age was 13.9 years (± 2.1). Evaluation of anthropometric data and determination of BMI at the 1st stage of the study allowed to identify 3 groups of patients: group 1 — adolescents with normal body weight, 40 people (33 %), group 2 — overweight, 48 people (40 %) and group 3 — obese, 33 adolescents (27 %). At stage 2nd, the analysis of the body structure using computer impedance, which allows to determine the composition of the body in a percentage.Results. When assessing the structure of the body, in group with normal body weight, the content of adipose tissue corresponds to the normal value. In adolescents overweight and obesity in 100 % of cases there was an increased content of fat mass. In the group of adolescents with normal body weight, the percentage deviation of AKM is 16–17 %, in the group with excess body weight 12–40 %. Insufficient as well as excessive percentage of AKM causes hunger. The higher AKM in full adolescents, the more difficult the process of weight loss. During the evaluation of the main metabolism it was found that in the group of obese patients the indicators exceeded those in the groups with normal and overweight.Conclusion. The use of bioimpedance analysis allows to create an optimal set of sequential effects aimed at correcting the fat mass, water composition and muscle mass of the patient, which determines a more directed and effective weight loss and the possibility of dynamic control.

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The methods for the characteristic of adipose tissue in the organism and their clinical significance

Abstract: -

Cited by 11 publications

References 25 publications

Heterogeneity of abdominal obesity in patients with cardiovascular diseases

Heterogeneity of abdominal obesity in patients with cardiovascular diseases

Clinical and Morphological Features of Lipomatous Hypertrophy of Interatrial Septum in Patients with Diseases of Cardiovascular System

Compositional Composition of the Body in Obese Children and Adolescents

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