1981
DOI: 10.1016/s0140-6736(81)90650-4
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THE METHYL FOLATE TRAP A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia

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Cited by 240 publications
(95 citation statements)
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“…The reason for the finding of low methionine is not clear. B 12 deficiency could be one explanation (64 ), but in samples with extremely low methionine (which consistently had increased folate), B 12 was in the high range and tHcy was within the reference interval. Nitrous oxide exposure, which inactivates methionine synthase and thereby leads to increased serum folate, low methionine, and increased tHcy (65 ), is yet another possibility.…”
Section: Relationship Between Methionine and Folatementioning
confidence: 99%
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“…The reason for the finding of low methionine is not clear. B 12 deficiency could be one explanation (64 ), but in samples with extremely low methionine (which consistently had increased folate), B 12 was in the high range and tHcy was within the reference interval. Nitrous oxide exposure, which inactivates methionine synthase and thereby leads to increased serum folate, low methionine, and increased tHcy (65 ), is yet another possibility.…”
Section: Relationship Between Methionine and Folatementioning
confidence: 99%
“…Thus, the findings in these babies are not consistent with nitrous oxide exposure. A third possibility is a primary methionine deficiency (64 ). Methionine is low in preterm infants before they receive amino acid supplementation (67 ) and may be low in infants before they start nursing.…”
Section: Relationship Between Methionine and Folatementioning
confidence: 99%
“…The observations that serum folate in infants (but not in older children) tended to be inversely associated with serum cobalamin and positively related to plasma MMA (Table 3) support this contention. However, long-term methylfolate trapping is expected to cause folate depletion (42 ), whereas these infants had high-normal whole-blood folate ( Table 2).…”
Section: Possible Mechanisms and Implications Of Increased Metabolitementioning
confidence: 99%
“…L'altération de la synthèse de l'ADN entraîne un blocage de la maturation cellulaire touchant d'abord les cellules à multiplication rapide d'où les manifestations hé-matologiques et cutanéo-muqueuses [74]. L'altération de la synthèse de la méthionine à partir de l'homocystéine se traduit par un défaut de synthèse de la protéine de base de la myéline ; ce défaut de synthèse est responsable de l'apparition des anomalies de la conduction nerveuse [14,31,70,73]. Les troubles neurologiques peuvent aussi être expliqués par le rôle de cofacteur de la vitamine B12 dans la régulation de la synthèse et de l'activité de certaines cytokines à tropisme neurologique [70,72,77].…”
Section: Absorption De La Vitamine B12 (Fig 2)unclassified