Alcoholic liver disease (ALD) is the most common chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which can eventually lead to cirrhosis and, in some cases, hepatocellular carcinoma (HCC). Alcoholic hepatitis (AH), a severe form of ASH, is an acute clinical decompensation related to liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL, but only a subset of individuals will have more advanced disease. Genetic, epigenetic, and environmental factors might explain the considerable interindividual variation in ALD phenotype. 1 BUrDen OF alCOHOl inTaKe in THe aMeriCan COnTinenT (nOrTH, CenTral anD sOUTH aMeriCa)Worldwide, 3 million people die annually of harmful alcohol consumption. According to the World Health Organization, in the entire American continent, the alcohol intake is classified as high and is constantly increasing. Annual per capita alcohol consumption in individuals older than 15 years is high in the American continent and gradually increases over time