The Michael donor–acceptor reactivity of curcumins in the synthesis of diverse multi-functional scaffolds

Abstract

Curcumin is a key constituent of turmeric with a variety of biological activities. From a chemical point of view, curcumin contains different functional groups that can undergo multiple transformations such...

Synthesis of fluorinated curcumin derivatives for detecting amyloid plaques by 19F-MRI

“…15,20 The functionalization at C4 can be performed by a Michael addition starting from curcumin. 21 Here, the synthesis of perfluoro curcumin derivatives MRI probes was carried out in four steps starting from commercial Curcuma longa powder (C1386, Merck), which is composed of curcumin (77%), demethoxycurcumin (17%), and bisdemethoxycurcumin (3%). Conjugation reactions take place on one or two hydroxyl groups of the phenyl rings of curcumin to synthesize mono- or bifunctional nonafluoro derivatives in a facile synthetic route.…”