The microbial and host factors that govern Candida gastrointestinal colonization and dissemination

Mishra, Animesh Anand; Koh, Andrew Y.

doi:10.1016/j.mib.2021.05.012

Cited by 11 publications

(10 citation statements)

References 59 publications

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“…Self-medication or use of prescript broad-spectrum antibiotics could be a frequent cause in the reduction of the normal bacterial flora, thus leading to excessive proliferation of intestinal yeast cells represented by Candida spp. [20]. Indeed, it has been shown that broad-spectrum antibiotics in particular improve fungal colonization and the risk of candidiasis by destroying competing bacterial flora [21].…”

Section: Discussionmentioning

confidence: 99%

Assessing Health Threats of Residents Living Close to Household Refuse Collection Points in Yaoundé, Centre Region, Cameroon

Lucia

Irma

Halmata

et al. 2022

IJTDH

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Aims: Household wastes constitute favorable environment for the development of human pathogens, posing thus important public health problem in the absence of appropriate waste management. This study aimed to assess health problems of people living close to household refuse collection points in the city of Yaoundé. Study Design: The prospective and cross-sectional study consisted of collecting stool samples from the populations in 12 quarters of Yaoundé around Hygiene and Sanitation in Cameroon refuse collection sites from November 2019 to February 2020. Methodology: Stool samples collected were treated with the formol ether and Kato-Katz technics. Questionnaires were administered to volunteer participants to evaluate risk factors related to contamination. Results: Of the 252 stool samples collected from participants aged 4 to 60 years, 209 (82.9%) individuals were infected with at least one species of intestinal pathogens. The pathogens identified belong to Helminthes (16.7%): Ascaris lumbricoides (12.3%), Trichirus trichiura (3.2%), hookworms (5.5%), to Protozoa: Entamoeba histolytica (11.5%), Entamoeba coli (13.5%), and Yeast Candida spp. (76.1%). Infection rate varied significantly by neighborhood (P= 0.02). The distance between residence and the collection point (P= 0.004); hand washing with soap before meals (P = 0.001); frequency of abdominal pain (P= 0.001); the date of the last deworming (P= 0.003); promiscuity (P= 0.005); source of water supply (P= 0.002) and the distance between the water source and the collection point (P = 0.006) were the main risk factors for the transmission of intestinal parasitosis. Conclusion: The results of this study show that people living close to HYSACAM dumpsites could be exposed to high risk of contamination of pathogens which develop and are propagated from these areas. An appropriate management house hood wastes collection point is indispensable in maintaining the neighborhood population in a healthy status.

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Section: Discussionmentioning

confidence: 99%

Assessing Health Threats of Residents Living Close to Household Refuse Collection Points in Yaoundé, Centre Region, Cameroon

Lucia

Irma

Halmata

et al. 2022

IJTDH

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“… 64 , 65 , 80 , 81 , 82 Importantly, gut colonization and fitness of C. albicans are influenced by crucial parameters, including its genetic determinants, interaction with the gut microbiome, metabolic adaptation, and host-defense mechanisms ( Figure 2 A). 83 Several genetic determinants have been implicated in C. albicans gut commensalism and competitive fitness. 83 For instance, SFU1 , a transcription factor regulating iron-uptake genes, has been shown to promote colonization and persistence in the gut ( Figure 2 A-i).…”

Section: Candida Albicans : Gut Commensalism and Competitive...mentioning

confidence: 99%

“… 83 Several genetic determinants have been implicated in C. albicans gut commensalism and competitive fitness. 83 For instance, SFU1 , a transcription factor regulating iron-uptake genes, has been shown to promote colonization and persistence in the gut ( Figure 2 A-i). 84 Another transcription factor, WOR1 , an epigenetic regulator of white-to-opaque switching in C. albicans , induces the distinct GUT ( g astrointestinally ind u ced t ransition) cell type that is functionally adapted for GIT colonization and persistence.…”

Section: Candida Albicans : Gut Commensalism and Competitive...mentioning

confidence: 99%

Candida albicans-enteric viral interactions—The prostaglandin E2 connection and host immune responses

Mochochoko¹,

Pohl²,

O’Neill³

2023

iScience

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“…Some pathogenicity traits of C . albicans have been identified in the gastrointestinal tract [ 8 ]. The generation of isogenic mutants of the highly virulent reference isolate SC5314 and within-host evolution experiments with SC5314 allowed the identification of genetic determinants that govern the ability of C .…”

Section: Introductionmentioning

confidence: 99%

Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation

et al. 2022

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As part of the human microbiota, the fungus Candida albicans colonizes the oral cavity and other mucosal surfaces of the human body. Commensalism is tightly controlled by complex interactions of the fungus and the host to preclude fungal elimination but also fungal overgrowth and invasion, which can result in disease. As such, defects in antifungal T cell immunity render individuals susceptible to oral thrush due to interrupted immunosurveillance of the oral mucosa. The factors that promote commensalism and ensure persistence of C. albicans in a fully immunocompetent host remain less clear. Using an experimental model of C. albicans oral colonization in mice we explored fungal determinants of commensalism in the oral cavity. Transcript profiling of the oral isolate 101 in the murine tongue tissue revealed a characteristic metabolic profile tailored to the nutrient poor conditions in the stratum corneum of the epithelium where the fungus resides. Metabolic adaptation of isolate 101 was also reflected in enhanced nutrient acquisition when grown on oral mucosa substrates. Persistent colonization of the oral mucosa by C. albicans also correlated inversely with the capacity of the fungus to induce epithelial cell damage and to elicit an inflammatory response. Here we show that these immune evasive properties of isolate 101 are explained by a strong attenuation of a number of virulence genes, including those linked to filamentation. De-repression of the hyphal program by deletion or conditional repression of NRG1 abolished the commensal behaviour of isolate 101, thereby establishing a central role of this factor in the commensal lifestyle of C. albicans in the oral niche of the host.

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The microbial and host factors that govern Candida gastrointestinal colonization and dissemination

Cited by 11 publications

References 59 publications

Assessing Health Threats of Residents Living Close to Household Refuse Collection Points in Yaoundé, Centre Region, Cameroon

Assessing Health Threats of Residents Living Close to Household Refuse Collection Points in Yaoundé, Centre Region, Cameroon

Candida albicans-enteric viral interactions—The prostaglandin E2 connection and host immune responses

Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation

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