The microbial toxicity of quaternary ammonium ionic liquids is dependent on the type of lipopolysaccharide

Kowalczyk, Paweł; Borkowski, Andrzej; Czerwonka, Grzegorz; Cłapa, Tomasz; Cieśla, Jolanta; Misiewicz, A; Borowiec, Marta; Szala, Mateusz

doi:10.1016/j.molliq.2018.06.102

Cited by 46 publications

(128 citation statements)

References 29 publications

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“…The estimations were made using the minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) method described previously by Kowalczyk [ 23 , 51 ]. The obtained results were statistically significant at the p < 0.05 level, measured by the Student’s t -test.…”

Section: Methodsmentioning

confidence: 99%

“…Despite a rather high bacterial colonization, the oral cavity is actually relatively resistant to infection due to innate host defense mechanisms and biologically active components of the saliva. Moreover, mutual interaction between nonspecific and specific microorganisms present in the mouth helps to create and maintain homeostasis [ 16 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, vitamin D, except for its effects on bone metabolism, has antimicrobial and anti-inflammatory properties, as well as healing and tissue regeneration potential. Available results suggest that the abnormal level of vitamin D may be connected with the development of periodontitis [ 14 , 23 ]. An in vitro study conducted by the Jagiellonian Innovation Center showed that dietary supplement Salistat SGL03, available on the Polish market inhibits growth of pathogens—S treptococcus pyogenes , Streptococcus sanguinis , Streptococcus mutans [ 4 , 7 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Ligilactobacillus salivarius and Other Natural Components against Anaerobic Periodontal Bacteria

Kucia¹,

Wietrak²,

Szymczak

et al. 2020

Molecules

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In this present study, the bacteriostatic effect of Salistat SGL03 and the Lactobacillus salivarius strain contained in it was investigated in adults in in vivo and in vitro tests on selected red complex bacteria living in the subgingival plaque, inducing a disease called periodontitis, i.e., chronic periodontitis. Untreated periodontitis can lead to the destruction of the gums, root cementum, periodontium, and alveolar bone. Anaerobic bacteria, called periopathogens or periodontopathogens, play a key role in the etiopathogenesis of periodontitis. The most important periopathogens of the oral microbiota are: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and others. Our hypothesis was verified by taking swabs of scrapings from the surface of the teeth of female hygienists (volunteers) on full and selective growth media for L. salivarius. The sizes of the zones of growth inhibition of periopathogens on the media were measured before (in vitro) and after consumption (in vivo) of Salistat SGL03, based on the disk diffusion method, which is one of the methods of testing antibiotic resistance and drug susceptibility of pathogenic microorganisms. Additionally, each of the periopathogens analyzed by the reduction inoculation method, was treated with L. salivarius contained in the SGL03 preparation and incubated together in Petri dishes. The bacteriostatic activity of SGL03 preparation in selected periopathogens was also analyzed using the minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) tests. The obtained results suggest the possibility of using the Salistat SGL03 dietary supplement in the prophylaxis and support of the treatment of periodontitis—already treated as a civilization disease.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Ligilactobacillus salivarius and Other Natural Components against Anaerobic Periodontal Bacteria

Kucia¹,

Wietrak²,

Szymczak

et al. 2020

Molecules

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“…ILs can strongly interact with both bacterial and eukaryotic cells to cause lethal or cytostatic effects. [7][8][9][10][11][12][13][14][15][16] Similarly, nanomaterials can also exhibit toxic properties. [17][18][19][20][21][22] However, studies concerning the toxicity of ILs and nanomaterials are usually conducted separately.…”

Section: Introductionmentioning

confidence: 99%

Ionic liquids strongly affect the interaction of bacteria with magnesium oxide and silica nanoparticles

2019

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“…It was found that they exhibited different level of sensitivity to ILs in terms of growth kinetics and viability. Three debatable notions have noticed from different studies: i) there are differences between the effects of ILs on Gram‐positive and Gram‐negative bacteria, ii) no discernible difference between the effects on the two types of bacteria, iii) insufficient evidence to draw definitive conclusions on the effects on the bacteria types . For example, Gram‐positive B. subtilis was more resistant to imidazolium‐based hydrophilic ILs, whereas Gram‐negative Pseudomonas aeruginosa exhibited more tolerance to choline‐ and phosphonium‐based ILs .…”

Section: Toxicity Of Ionic Liquids Toward Microorganismsmentioning

confidence: 99%

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

Sivapragasam

Moniruzzaman

Goto

2020

Biotechnology Journal

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Ionic liquids (ILs), a class of materials with unique physicochemical properties, have been used extensively in the fields of chemical engineering, biotechnology, material sciences, pharmaceutics, and many others. Because ILs are very polar by nature, they can migrate into the environment with the possibility of inclusion in the food chain and bioaccumulation in living organisms. However, the chemical natures of ILs are not quintessentially biocompatible. Therefore, the practical uses of ILs must be preceded by suitable toxicological assessments. Among different methods, the use of microorganisms to evaluate IL toxicity provides many advantages including short generation time, rapid growth, and environmental and industrial relevance. This article reviews the recent research progress on the toxicological properties of ILs toward microorganisms and highlights the computational prediction of various toxicity models.

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The microbial toxicity of quaternary ammonium ionic liquids is dependent on the type of lipopolysaccharide

Cited by 46 publications

References 29 publications

Effect of Ligilactobacillus salivarius and Other Natural Components against Anaerobic Periodontal Bacteria

Effect of Ligilactobacillus salivarius and Other Natural Components against Anaerobic Periodontal Bacteria

Ionic liquids strongly affect the interaction of bacteria with magnesium oxide and silica nanoparticles

An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

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