The microbiological analysis of the effectiveness of modern antiseptics and antimicrobial materials

Abstract

Effectiveness of antiseptics decasan ® (DC), chlorhexidine digluconate (CH), miramistin (MR), antimicrobial composition of decamethoxin (AMC, patent N 74853, Ukraine), antimicrobial dressings against isolated strains of S. aureus (n 32), E. соli (n 25), P. aeruginosa (n 20), C. albicans (n 16) in patients with diabetes having pyo-inflammatory complications has been researched. The antimicrobial properties of antiseptics have been studied by means of the serial dilutions method. The antimicrobial activity of dressings (1.0x1.0 cm), such as medical cotton impregnated with AMC; antiseptic overlay with CH (AOCH); Traumastem Biodress Disinfect ® (TBD); activtex CH ® , activtex CHF ® , against clinical isolates of microorganisms has been studied on solid media. The bactericidal action against S. aureus in the presence of AMC (1.4±0.2 мkg/ml), DC (1.73±0.2 мkg/ml); CH (12.8±2.1 мkg/ml); MR (8.3±0.9 мkg/ml) has been found. The bactericidal properties of DC and MR in relation to E. соli in their concentrations of 6.68±0.71 and 17.9±1.9 мkg/ml, respectively, have been determined. AMC (4.9±0.5 мkg/ml) was six times more active than CH (р<0.001). The antipseudomonal action of DC against P. aeruginosa was 1.5 times higher than CH. AMC had also 2.8 times higher activity (р<0.001). The bactericidal action of MR was registered in the presence of 72.9±2.2 мkg/ml. It has been found that C. albicans is sensitive to AMC (7.4±1.9 мkg/ml), DC (14.6±1.9 мkg/ml), MR (26.0±3.6 мkg/ml). CH has a low effectiveness in relation to C. albicans (32.8±7.4 мkg/ml). Advantages of the antimicrobial activity of modern antimicrobial dressings with AMC against S. aureus, E. coli, P. aeruginosa, fungi of Candida genus have been found. О.А.Назарчук-канд. мед. наук, асистент кафедри мікробіології Вінницького національного медичного університету ім. М.І.Пирогова