The microbiome and mental health: Hope or hype?

Taylor, Valerie H.

doi:10.1503/jpn.190110

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…An increasing amount of evidence strongly supports the crucial role of the human microbiome in human health and disease [67][68][69]. As a result, the microbiota has become an attractive target for potential therapeutics [70].…”

Section: Modulation Of Inflammation and Activation Of Intracellular Amentioning

confidence: 99%

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

et al. 2020

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Mismanagement of bacterial infection therapies has undermined the reliability and efficacy of antibiotic treatments, producing a profound crisis of the antibiotic drug market. It is by now clear that tackling deadly infections demands novel strategies not only based on the mere toxicity of anti-infective compounds. Host-directed therapies have been the first example as novel treatments with alternate success. Nevertheless, recent advances in the human microbiome research have provided evidence that compounds produced by the microbial metabolism, namely postbiotics, can have significant impact on human health. Such compounds target the host-microbe-pathogen interface rescuing biotic and immune unbalances as well as inflammation, thus providing novel therapeutic opportunities. This work discusses critically, through literature review and personal contributions, these novel nonantibiotic treatment strategies for infectious disease management and resistance prevention, which could represent a paradigm change rocking the foundation of current antibiotic therapy tenets.

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Section: Modulation Of Inflammation and Activation Of Intracellular Amentioning

confidence: 99%

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

et al. 2020

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“…For example, the human colon microbiota is constituted by 100 to 300 different bacterial taxa together with dozens of fungi, archaea and viruses (Hillman et al, 2017). Also, different protists, bacteria, archaea, and viruses live in association with corals (Thompson et al, 2015;Bourne et al, 2016), whereas the bacteria covering the cuticle of two Neotropical ants belong to at least ten different phyla (Birer et al, 2017) Besides the importance of microbes in hosts' physical and mental health and even in their social behavior (Cho and Blaser, 2012;Mattoso et al, 2012;Valdes et al, 2018;Taylor, 2019;Sherwin et al, 2019), species rich soil microbiota are essential for maintaining the functioning of terrestrial ecosystems. They are involved in decomposing organic materials and in maintaining biogeochemical cycles of nitrogen and carbon (Bardgett et al, 2008;Jacoby et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Density-dependent private benefit leads to bacterial mutualism

Jimenez¹,

Scheuring

2020

Preprint

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Microorganisms produce materials leaked from the cell which are beneficial for themselves and their neighbors. We modeled the situation when cells can produce different costly secretions which increase the carrying capacity of the population. Strains that lose the function of producing one or more secretions avoid the cost of production and can exhaust the producers. However, secreting substances provides a private benefit for the producers in a density-dependent way. We developed a model to examine the outcome of the selection among different type of producer strains from the non-producer strain to the partial producers, to the full producer one. We were particularly interested in circumstances under which selection maintains partners that produce complementary secreted materials thus forming an interdependent mutualistic interaction.We show that interdependent mutualism is selected under broad range of conditions if private benefit decreases with density. Selection frequently causes the coexistence of more and less generalist cooperative strains, thus cooperation and exploitation co-occur. Interdependent mutual-ism is evolved under more specific circumstances if private benefit increases with density and these general observations are valid in a well-mixed and in a structured deme model. We show that the applied population structure supports cooperation in general, which, depending on the level of private benefit and intensity of mixing helps either the specialist or the generalist cooperators.

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“…2020), and even the mental health (Sherwin et al. 2019; Taylor 2019; Järbrink‐Sehgal and Andreasson 2020) or social behavior (Archie and Tung 2015) of the animal hosts are notably shaped by their interaction with symbiotic microbiome.…”

mentioning

confidence: 99%

Density‐dependent private benefit leads to bacterial mutualism

Jimenez

Scheuring

2021

Evolution

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Microorganisms produce and secrete materials that are beneficial for themselves and their neighbors. We modeled the situation when cells can produce different costly secretions which increase the carrying capacity of the population. Strains that lose the function of producing one or more secretions avoid the cost of production and can exhaust the producers. However, secreting substances provides a private benefit for the producers in a density-dependent way. We developed a model to examine the outcome of the selection among different types of producer strains from the nonproducer strain to the partial producers, to the full producer strain. We were interested in circumstances under which selection maintains partners that produce complementary secreted materials thus forming an interdependent mutualistic interaction. We show that interdependent mutualism is selected under a broad range of conditions if private benefit decreases with density. Selection frequently causes the coexistence of more and less generalist cooperative strains, thus cooperation and exploitation co-occur. Interdependent mutualism is evolved under more specific circumstances if private benefit increases with density and these general observations are valid in a well-mixed and a structured deme model. We show that the applied population structure allows the invasion of rare cooperators and supports cooperation in general.

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The microbiome and mental health: Hope or hype?

Cited by 17 publications

References 18 publications

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

Density-dependent private benefit leads to bacterial mutualism

Density‐dependent private benefit leads to bacterial mutualism

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