The Microbiome in Neurogastroenterology

Preidis, Geoffrey A.; Chumpitazi, Bruno P.; Shulman, Robert J.

doi:10.1007/978-3-319-43268-7_5

Cited by 1 publication

(1 citation statement)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52 Nonetheless, given that intestinal motility could influence both appetite and the efficiency of energy extraction from ingested nutrients, these data highlight the intersection of diet, microbiota, and neurogastroenterology as an important area of future research. 53 Dietary deficiencies also can alter the microbiota. Deletion of the mouse angiotensin I converting enzyme (peptidyl-dipeptidase) 2 (Ace2), which is required for the expression of an enterocyte amino acid transporter, results in tryptophan deficiency with microbial dysbiosis that is due to transcriptional repression of ileal antimicrobial peptides.…”

Section: Dietary Factors That Alter the Gut Microbiome In Undernutritionmentioning

confidence: 99%

Mechanisms of cross-talk between the diet, the intestinal microbiome, and the undernourished host

2016

Self Cite

View full text Add to dashboard Cite

Undernutrition remains one of the most pressing global health challenges today, contributing to nearly half of all deaths in children under five years of age. Although insufficient dietary intake and environmental enteric dysfunction are often inciting factors, evidence now suggests that unhealthy gut microbial populations perpetuate the vicious cycle of pathophysiology that results in persistent growth impairment in children. The metagenomics era has facilitated new research identifying an altered microbiome in undernourished hosts and has provided insight into a number of mechanisms by which these alterations may affect growth. This article summarizes a range of observational studies that highlight differences in the composition and function of gut microbiota between undernourished and healthy children; discusses dietary, environmental and host factors that shape this altered microbiome; examines the consequences of these changes on host physiology; and considers opportunities for microbiome-targeting therapies to combat the global challenge of child undernutrition.

show abstract

Section: Dietary Factors That Alter the Gut Microbiome In Undernutritionmentioning

confidence: 99%