The microbiome modulating activity of bile acids

Tian, Yuan; Gui, Weihua; Koo, Imhoi; Smith, Philip B.; Allman, Erik; Nichols, Robert G.; Rimal, Bipin; Cai, Jingwei; Liu, Qing; Patterson, Andrew D.

doi:10.1080/19490976.2020.1732268

Cited by 155 publications

(104 citation statements)

References 53 publications

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“…Bile acids are crucial for the emulsification of lipids and for maintaining hepatic glucose homeostasis, and they exert a strong antimicrobial effect owing to their detergent properties, which likely change the environment of gut microbiota by inhibiting the growth of susceptible bacteria. Although bile acid tolerance shows a strain-specific feature, Gram-negative bacteria are generally more resistant to the antimicrobial effects of bile acids than Gram-positive bacteria 6,30 .…”

Section: Discussionmentioning

confidence: 99%

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or fibrosis severity. Significant alterations in microbiome diversity are observed according to fibrosis severity in non-obese, but not obese, subjects. Ruminococcaceae and Veillonellaceae are the main microbiota associated with fibrosis severity in non-obese subjects. Furthermore, stool bile acids and propionate are elevated, especially in non-obese subjects with significant fibrosis. Fibrosis-related Ruminococcaceae and Veillonellaceae species undergo metagenome sequencing, and four representative species are administered in three mouse NAFLD models to evaluate their effects on liver damage. This study provides the evidence for the role of the microbiome in the liver fibrosis pathogenesis, especially in non-obese subjects.

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Section: Discussionmentioning

confidence: 99%

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

et al. 2020

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“…BA interruption by BA sequestrants is able to affect Carbohydrate-response element-binding protein (ChREBP) transactivity, subsequently influencing aerobic glycolysis through p53 inhibition ( Iizuka, 2017 ). Also, BAs could potently modulate microbiome ( Tian et al., 2020 ), and microbial communities provide molecules and metabolites, which are essential for glycolysis ( Belizario et al., 2018 ). It has been suggested that hypoxia could repress BA synthesis through inhibition of CYP7A1 expression ( Moon et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of Hypoxia-Associated Signature in Pan-Cancer

Zhang

Huang

et al. 2020

iScience

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Summary Hypoxia is serving crucial roles in cancers. This study aims to comprehensively analyze the molecular features and clinical relevance of a well-defined hypoxia-associated signature in pan-cancer using multi-omics data. Data were acquired from TCGA, CCLE, GDSC, and GEO. RNA expression pattern, copy number variation (CNV), methylation, and mutation of the signature were analyzed. The majority of the 15 genes were upregulated in cancer tissues compared with normal tissue, and RNA expression was negatively associated with methylation level. CNV occurred in almost all the cancers, whereas mutation frequency was low across different cancer types. The signature was also closely related to cancer hallmarks and cancer-related metabolism pathways. NDRG1 was upregulated in kidney cancer tissues as indicated by immunohistochemistry. Besides, most of the 15 genes were risk factors for patients' overall survival. Our results provide a valuable resource that will guide both mechanistic and therapeutic analyses of the hypoxia signature in cancers.

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“…There is a two-way interaction between bile acid and intestinal microbial composition. 51 Bile acid can change the bacterial community structure, affect host metabolism, 52 regulate liver lipid, glucose and energy balance, and maintain metabolic balance. 53 Bile acid can also induce WAT browning by activating G protein-coupled bile acid receptor 1 (TGR5) 54 or directly or indirectly affect glucose metabolism and insulin signal transduction through lipid emulsification, affecting the cell membrane and inducing ectopic functions and receptors (such as liver farnesol X receptor (FXR) and G protein-coupled receptor (GPCR)).…”

Section: Regulate the Levels Of Bile Acids And Other Metabolitesmentioning

confidence: 99%

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

Li¹,

Zhang²,

Li³

2020

DMSO

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Obesity is the lipid deposition caused by the imbalance between energy intake and consumption caused by a variety of factors. Obesity can lead to multiple systemic complications. At present, the treatment of obesity is mainly lifestyle intervention, drug weight loss, and weight loss surgery, but the curative effect is limited or the side effects are serious. Traditional Chinese medicine plays a unique role in the treatment of obesity. Existing studies have found that traditional Chinese medicine can treat obesity in a variety of ways, such as regulating intestinal microflora, enhancing hormone level, regulating fat metabolism, and so on. In this review, we will introduce and summarize the mechanism of traditional Chinese medicine in the treatment of obesity.

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The microbiome modulating activity of bile acids

Cited by 155 publications

References 53 publications

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

Integrative Analysis of Hypoxia-Associated Signature in Pan-Cancer

<p>The Mechanism of Traditional Chinese Medicine for the Treatment of Obesity</p>

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