The Microbiomes of Pancreatic Tissue in Pancreatic Cancer and Non-Cancer Subjects

Abstract

Objective: To determine whether bacteria are present in the pancreas of pancreatic cancer and non-cancer subjects and examine whether bacterial profiles vary by site and disease phenotype.Design: 77 patients requiring surgery for pancreatic diseases, or diseases of the foregut, at the Rhode Island Hospital (RIH) were recruited into this study between 2014 and 2016. In addition, 36 whole pancreas were obtained from the National Disease Research Interchange (NDRI) from subjects who were of similar age as the RIH patients and had not died of cancer. The primary exposure of interest was the measurement of the relative abundance of bacterial taxa in all tissue specimens using 16S rRNA gene sequencing.

Microbiota and cancer (review of literature)

“…матке, плаценте, мочевом пузыре и желудочнокишечном тракте [5][6][7][8][9][10][11][12]. Сравнительно недавно появились данные о бактериях, выявленных при помощи культуральных и метагеномных методов исследования в головном мозге [13,14].…”