The Microbiota–Gut–Brain Axis in Behaviour and Brain Disorders

Lana, Daniele; Giovannini, Maria Grazia

doi:10.3390/ijms24108460

Cited by 4 publications

(1 citation statement)

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“…However, the concentration of acetylcholine in faeces steadily increased during and after pregnancy. Previous studies have indicated that the gut microbiota can influence the central nervous system by synthesising neuroactive compounds or regulating the secretion of neurotransmitters, such as acetylcholine, to regulate cognition [ 50 , 51 ]. In this study, the abundance of Flavonifractor was positively correlated with the faecal acetylcholine level.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of the Gut Microbiota and Faecal and Serum Metabolomes during Pregnancy—A Longitudinal Study

Pan,

Guo,

Chen

et al. 2024

Nutrients

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Normal pregnancy involves numerous physiological changes, including changes in hormone levels, immune responses, and metabolism. Although several studies have shown that the gut microbiota may have an important role in the progression of pregnancy, these findings have been inconsistent, and the relationship between the gut microbiota and metabolites that change dynamically during and after pregnancy remains to be clarified. In this longitudinal study, we comprehensively profiled the temporal dynamics of the gut microbiota, Bifidobacterium communities, and serum and faecal metabolomes of 31 women during their pregnancies and postpartum periods. The microbial composition changed as gestation progressed, with the pregnancy and postpartum periods exhibiting distinct bacterial community characteristics, including significant alterations in the genera of the Lachnospiraceae or Ruminococcaceae families, especially the Lachnospiraceae FCS020 group and Ruminococcaceae UCG-003. Metabolic dynamics, characterised by changes in nutrients important for fetal growth (e.g., docosatrienoic acid), anti-inflammatory metabolites (e.g., trans-3-indoleacrylic acid), and steroid hormones (e.g., progesterone), were observed in both serum and faecal samples during pregnancy. Moreover, a complex correlation was identified between the pregnancy-related microbiota and metabolites, with Ruminococcus1 and Ruminococcaceae UCG-013 making important contributions to changes in faecal and serum metabolites, respectively. Overall, a highly coordinated microbiota–metabolite regulatory network may underlie the pregnancy process. These findings provide a foundation for enhancing our understanding of the molecular processes occurring during the progression of pregnancy, thereby contributing to nutrition and health management during this period.

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Section: Discussionmentioning

confidence: 99%