The microbiota link to irritable bowel syndrome

Jeffery, Ian B.; Quigley, Eamonn Martin; Öhman, Lena; Simrén, Magnus; O’Toole, Paul W.

doi:10.4161/gmic.21772

Cited by 105 publications

(67 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, members of the genus Bacteroides were found to be present at a lower level in paediatric patients with IBS than in the healthy controls and an increase in Alistipes was linked with a greater frequency of pain [Saulnier et al 2011]. Other work by Jeffery and colleagues found subgroups among the patients with IBS with varying microbial signatures, however generally an increase in the Firmicutes to Bacteroidetes ratio was evident in patients with IBS who differed from normal populations [Jeffery et al 2012b[Jeffery et al , 2012c. These HTS studies suggest that a link between the gut microbiota and IBS may exist, which could, in time, lead to the design of therapeutic options.…”

Section: Irritable Bowel Syndromementioning

confidence: 97%

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Guinane

Cotter

2013

Therap Adv Gastroenterol

704

447

View full text Add to dashboard Cite

Abstract:The human gut microbiota has become the subject of extensive research in recent years and our knowledge of the resident species and their potential functional capacity is rapidly growing. Our gut harbours a complex community of over 100 trillion microbial cells which influence human physiology, metabolism, nutrition and immune function while disruption to the gut microbiota has been linked with gastrointestinal conditions such as inflammatory bowel disease and obesity. Here, we review the many significant recent studies that have centred on further enhancing our understanding of the complexity of intestinal communities as well as their genetic and metabolic potential. These have provided important information with respect to what constitutes a 'healthy gut microbiota' while furthering our understanding of the role of gut microbes in intestinal diseases. We also highlight recently developed genomic and other tools that are used to study the gut microbiome and, finally, we consider the manipulation of the gut microbiota as a potential therapeutic option to treat chronic gastrointestinal disease.

show abstract

Section: Irritable Bowel Syndromementioning

confidence: 97%

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Guinane

Cotter

2013

Therap Adv Gastroenterol

704

447

View full text Add to dashboard Cite

show abstract

“…The Walkerton, Ontario Canada Campylobacter outbreak patients who were followed for a number of years post infection provide data linking infection, inflammation, barrier function and IBS (Marshall et al, 2004). However, a convincing history of enteritis with onset of IBS is present only in a subset of patients with IBS (Jeffery, Quigley, Öhman, Simrén, & O'Toole, 2012). The literature reveals inconsistencies as to whether pro-and/or anti-inflammatory cytokines are altered in IBS patients (Chang et al, 2012;Schmulson et al, 2012).…”

Section: Immune Functionmentioning

confidence: 97%

Update on Irritable Bowel Syndrome Program of Research

2013

View full text Add to dashboard Cite

Purpose: This article provides an update and overview of a nursing research program focused on understanding the pathophysiology and management of irritable bowel syndrome (IBS). Methods: This review includes English language papers from the United States, Europe, and Asia (e.g., South Korea) from 1999 to 2013. We addressed IBS as a health problem, emerging etiologies, diagnostic and treatment approaches and the importance of a biopsychosocial model. Results: IBS is a chronic, functional gastrointestinal disorder characterized by recurrent episodes of abdominal pain and alterations in bowel habit (diarrhea, constipation, mixed). It is a condition for which adults, particularly women ages 20-45, seek health care services in both the United States and South Korea. Clinically, nurses play key roles in symptom prevention and management including designing and implementing approaches to enhance the patients' self-management strategies. Multiple mechanisms are believed to participate in the development and maintenance of IBS symptoms including autonomic nervous system dysregulation, intestinal inflammation, intestinal dysbiosis, dietary intolerances, alterations in emotion regulation, heightened visceral pain sensitivity, hypothalamic-pituitary-adrenal dysregulation, and dysmotility. Because IBS tends to occur in families, genetic factors may also contribute to the pathophysiology. Patients with IBS often report a number of co-morbid disorders and/or symptoms including poor sleep. Conclusion: The key to planning effective management strategies is to understand the heterogeneity of this disorder. Interventions for IBS include non-pharmacological strategies such as cognitive behavior therapy, relaxation strategies, and exclusion diets.

show abstract

“…[51] Indeed, IBS is associated with altered microbiota composition, at least in a substantial subset of patients. [123,124] Furthermore, the microbiota has been causally implicated in IBS in two studies utilising fecal microbiota transplant. [125,126] By transferring the microbiota from IBS patients into healthy mice, characteristic symptoms of IBS gastrointestinal dysfunction can be induced, including accelerated gastrointestinal transit and increased intestinal permeability.…”

Section: Microbial Signals Modulate Visceral Painmentioning

confidence: 99%

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

et al. 2017

View full text Add to dashboard Cite

The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18

show abstract

The microbiota link to irritable bowel syndrome

Cited by 105 publications

References 55 publications

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Update on Irritable Bowel Syndrome Program of Research

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

Contact Info

Product

Resources

About