The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders

Abstract

miR-17 ~ 92, an miRNA family containing three paralogous polycistronic clusters, was initially considered as an oncogene and was later demonstrated to trigger various physiological and pathological processes. Emerging evidence has implicated miR-17 ~ 92 family as a master regulator of neurogenesis. Through targeting numerous genes that affect cell cycle arrest, stemness deprivation, and lineage commitment, miR-17 ~ 92 family controls the proliferation and neuronal differentiation of neural stem/progenitor cells in both developmental and adult brains. Due to the essential roles of miR-17 ~ 92 family, its misexpression is widely associated with acute and chronic neurological disorders by attenuating neurogenesis and facilitating neuronal apoptosis. The promising neurogenic potential of miR-17 ~ 92 family also makes it a promising “medicine” to activate the endogenous and exogenous regenerative machinery, thus enhance tissue repair and function recovery after brain injury. In this review, we focus on the recent progress made toward understanding the involvement of miR-17 ~ 92 family in regulating both developmental and adult neurogenesis, and discuss the regenerative potential of miR-17 ~ 92 family in treating neurological disorders.

microRNAs as the biomarkers of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

“…Increased levels of miRNA-23a-3p inhibit the CXC chemokine receptor 4 (CXCR4) in spinal glial cells, which is directly responsible for neuropathic pain. miR-17-92 cluster (containing: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92a-1) is an important factor regulating neurogenesis, neuronal differentiation and showing great potential in the treatment of neurodegenerative diseases [38,39]. In our study, we observed an increase in the expression of most of the miRNAs in this family.…”

MicroRNAs within Basal-Like Signature of Quadruple Negative Breast Cancer Impact Overall Survival in African Americans

“…Secondly, mir-17 and 20a expressions were higher in overall AR-negative and QNBC samples. MYC positively regulates mir-17 and 20a (38) (39). MYC expression was higher in QNBCs, and FOXA1 was lower in QNBCs.…”

CNBA: Coregulatory Network Builder and Analyzer

“…al. these 3 miRNAs share the same seed sequence and thus are thus predisposed to clustering closely [37]. The role of miR-17/92 in tumorigenesis in humans and consequent effect on aging due their dysregulation have been demonstrated already [38,39].…”